Immunotherapy and radiation therapy sequencing: State of the data on timing, efficacy, and safety.
cancer therapy sequencing
immune checkpoint blockade
immunotherapy
radiation therapy
radiosensitization
Journal
Cancer
ISSN: 1097-0142
Titre abrégé: Cancer
Pays: United States
ID NLM: 0374236
Informations de publication
Date de publication:
15 05 2021
15 05 2021
Historique:
revised:
16
11
2020
received:
05
10
2020
accepted:
17
11
2020
pubmed:
24
2
2021
medline:
31
12
2021
entrez:
23
2
2021
Statut:
ppublish
Résumé
Radiation therapy exerts a tumoricidal local effect as well as both local and systemic immunomodulation. Immune checkpoint blockade has become a widely used treatment modality across cancer types with a rapidly growing list of agents and US Food and Drug Administration-approved indications. Moreover, there may be synergy between radiation therapy and immune checkpoint blockade. Various strategies have been used, but the optimal sequencing of these therapies is unclear. In this review, the authors discuss the major mechanisms of available immune checkpoint inhibitors and explore the available preclinical and clinical evidence regarding treatment sequencing. They also review safety considerations and conclude with possible future directions.
Identifiants
pubmed: 33620731
doi: 10.1002/cncr.33424
pmc: PMC9376883
mid: NIHMS1826087
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1553-1567Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2021 American Cancer Society.
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