Supporting smoking cessation and preventing relapse following a stay in a smoke-free setting: a meta-analysis and investigation of effective behaviour change techniques.
Smoking cessation
meta-analyses
relapse
smoke-free policy
smoking
systematic review
tobacco
Journal
Addiction (Abingdon, England)
ISSN: 1360-0443
Titre abrégé: Addiction
Pays: England
ID NLM: 9304118
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
16
12
2020
received:
08
10
2020
accepted:
10
02
2021
pubmed:
24
2
2021
medline:
9
10
2021
entrez:
23
2
2021
Statut:
ppublish
Résumé
Admission to a smoke-free setting presents a unique opportunity to encourage smokers to quit. However, risk of relapse post-discharge is high, and little is known about effective strategies to support smoking cessation following discharge. We aimed to identify interventions that maintain abstinence following a smoke-free stay and determine their effectiveness, as well as the probable effectiveness of behaviour change techniques (BCTs) used in these interventions. Systematic review and meta-analyses of studies of adult smokers aged ≥ 18 years who were temporarily or fully abstinent from smoking to comply with institutional smoke-free policies. Institutions included prison, inpatient mental health, substance misuse or acute hospital settings. A Mantel-Haenszel random-effects meta-analysis of randomized controlled trials (RCTs) was conducted using biochemically verified abstinence (7-day point prevalence or continuous abstinence). BCTs were defined as 'promising' in terms of probable effectiveness (if BCT was present in two or more long-term effective interventions) and feasibility (if BCT was also delivered in ≥ 25% of all interventions). Thirty-seven studies (intervention n = 9041, control n = 6195) were included: 23 RCTs (intervention n = 6593, control n = 5801); three non-randomized trials (intervention n = 845, control n = 394) and 11 cohort studies (n = 1603). Meta-analysis of biochemically verified abstinence at longest follow-up (4 weeks-18 months) found an overall effect in favour of intervention [risk ratio (RR) = 1.27, 95% confidence interval (CI) = 1.08-1.49, I A systematic review and meta-analyses indicate that behavioural and pharmacological support is effective in maintaining smoking abstinence following a stay in a smoke-free institution. Several behaviour change techniques may help to maintain smoking abstinence up to 18 months post-discharge.
Sections du résumé
BACKGROUND AND AIMS
Admission to a smoke-free setting presents a unique opportunity to encourage smokers to quit. However, risk of relapse post-discharge is high, and little is known about effective strategies to support smoking cessation following discharge. We aimed to identify interventions that maintain abstinence following a smoke-free stay and determine their effectiveness, as well as the probable effectiveness of behaviour change techniques (BCTs) used in these interventions.
METHODS
Systematic review and meta-analyses of studies of adult smokers aged ≥ 18 years who were temporarily or fully abstinent from smoking to comply with institutional smoke-free policies. Institutions included prison, inpatient mental health, substance misuse or acute hospital settings. A Mantel-Haenszel random-effects meta-analysis of randomized controlled trials (RCTs) was conducted using biochemically verified abstinence (7-day point prevalence or continuous abstinence). BCTs were defined as 'promising' in terms of probable effectiveness (if BCT was present in two or more long-term effective interventions) and feasibility (if BCT was also delivered in ≥ 25% of all interventions).
RESULTS
Thirty-seven studies (intervention n = 9041, control n = 6195) were included: 23 RCTs (intervention n = 6593, control n = 5801); three non-randomized trials (intervention n = 845, control n = 394) and 11 cohort studies (n = 1603). Meta-analysis of biochemically verified abstinence at longest follow-up (4 weeks-18 months) found an overall effect in favour of intervention [risk ratio (RR) = 1.27, 95% confidence interval (CI) = 1.08-1.49, I
CONCLUSIONS
A systematic review and meta-analyses indicate that behavioural and pharmacological support is effective in maintaining smoking abstinence following a stay in a smoke-free institution. Several behaviour change techniques may help to maintain smoking abstinence up to 18 months post-discharge.
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2978-2994Subventions
Organisme : Department of Health
ID : NIHR200607
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
Références
Peacock A., Leung J., Larney S., Colledge S., Hickman M., Rehm J., et al. Global statistics on alcohol, tobacco and illicit drug use: 2017 status report. Addiction 2018; 113: 1905-1926.
Richardson S., McNeill A., Brose L. S. Smoking and quitting behaviours by mental health conditions in Great Britain (1993-2014). Addict Behav 2019; 90: 14-19.
Szatkowski L., McNeill A. The delivery of smoking cessation interventions to primary care patients with mental health problems. Addiction 2013; 108: 1487-1494.
Glasheen C., Hedden S. L., Forman-Hoffman V. L., Colpe L. J. Cigarette smoking behaviors among adults with serious mental illness in a nationally representative sample. Ann Epidemiol 2014; 24: 776-780.
McClave A. K., McKnight-Eily L. R., Davis S. P., Dube S. R. Smoking characteristics of adults with selected lifetime mental illnesses: results from the 2007 National Health Interview Survey. Am J Public Health 2010; 100: 2464-2472.
Siru R., Hulse G. K., Tait R. J. Assessing motivation to quit smoking in people with mental illness: a review. Addiction 2009; 104: 719-733.
Brose L. S., Simonavicius E., McNeill A. Maintaining abstinence from smoking after a period of enforced abstinence-systematic review, meta-analysis and analysis of behaviour change techniques with a focus on mental health. Psychol Med 2018; 48: 669-678.
National Institute for Health and Care Excellence (NICE). Stop smoking interventions and services 2018. Available at: https://www.nice.org.uk/guidance/ng92/chapter/Rationale-and-impact
Prochaska J. J., Fletcher L., Hall S. E., Hall S. M. Return to smoking following a smoke-free psychiatric hospitalization. Am J Addict 2006; 15: 15-22.
Clarke J. G., Stein L. A., Martin R. A., Martin S. A., Parker D., Lopes C. E., et al. Forced smoking abstinence: not enough for smoking cessation. JAMA Intern Med 2013; 173: 789-794.
Mussulman L. M., Scheuermann T. S., Faseru B., Nazir N., Richter K. P. Rapid relapse to smoking following hospital discharge. Prev Med Rep 2019; 15: 100891.
Shmueli D., Fletcher L., Hall S. E., Hall S. M., Prochaska J. J. Changes in psychiatric patients’ thoughts about quitting smoking during a smoke-free hospitalization. Nicotine Tob Res 2008; 10: 875-881.
Rigotti N. A., Clair C., Munafò M. R., Stead L. F. Interventions for smoking cessation in hospitalised patients. Cochrane Database Syst Rev 2012; 5: CD001837.
Thurgood S. L., McNeill A., Clark-Carter D., Brose L. S. A systematic review of smoking cessation interventions for adults in substance abuse treatment or recovery. Nicotine Tob Res 2016; 18: 993-1001.
Lorencatto F., West R., Bruguera C., Brose L. S., Michie S. Assessing the quality of goal setting in Behavioural support for smoking cessation and its association with outcomes. Ann Behav Med Publ Soc Behav Med 2016; 50: 310-318.
Michie S., Abraham C., Whittington C., McAteer J., Gupta S. Effective techniques in healthy eating and physical activity interventions: a meta-regression. Health Psychol 2009; 28: 690-701.
Michie S., Atkins L., West R. The Behaviour Change Wheel: A Guide to Designing Interventions. England, UK: Silverback Publishing; 2014.
Michie S., Wood C. E., Johnston M., Abraham C., Francis J. J., Hardeman W. Behaviour change techniques: the development and evaluation of a taxonomic method for reporting and describing behaviour change interventions (a suite of five studies involving consensus methods, randomised controlled trials and analysis of qualitative data). Health Technol Assess 2015; 19: 1-188.
Michie S., Richardson M., Johnston M., Abraham C., Francis J., Hardeman W., et al. The behavior change technique taxonomy (v1) of 93 hierarchically clustered techniques: building an international consensus for the reporting of behavior change interventions. Ann Behav Med 2013; 46: 81-95.
Brown T. J., Hardeman W., Bauld L., Holland R., Maskrey V., Naughton F., et al. A systematic review of behaviour change techniques within interventions to prevent return to smoking postpartum. Addict Behav 2019; 92: 236-243.
Griffiths S. E., Parsons J., Naughton F., Fulton E. A., Tombor I., Brown K. E. Are digital interventions for smoking cessation in pregnancy effective? A systematic review and meta-analysis. Health Psychol Rev 2018; 12: 333-356.
Walker R. C., Graham A., Palmer S. C., Jagroop A., Tipene-Leach D. C. Understanding the experiences, perspectives and values of indigenous women around smoking cessation in pregnancy: systematic review and thematic synthesis of qualitative studies. Int J Equity Health 2019; 18: 74.
Cane J., O'Connor D., Michie S. Validation of the theoretical domains framework for use in behaviour change and implementation research. Implement Sci 2012; 7: 37.
Bussières A. E., Patey A. M., Francis J. J., Sales A. E., Grimshaw J. M., the Canada Prime Plus Team Identifying factors likely to influence compliance with diagnostic imaging guideline recommendations for spine disorders among chiropractors in North America: a focus group study using the theoretical domains framework. Implement Sci 2012; 7: 82.
Fulton E. A., Brown K. E., Kwah K. L., Wild S. StopApp: using the behaviour change wheel to develop an app to increase uptake and attendance at NHS stop smoking services. Healthcare (Basel) 2016; 4: 31.
Moher D., Liberati A., Tetzlaff J., Altman D. G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009; 339: b2535.
de Bruin M., Black N., Javornik N., Viechtbauer W., Eisma M. C., Hartman-Boyce J., et al. Underreporting of the active content of behavioural interventions: a systematic review and meta-analysis of randomised trials of smoking cessation interventions. Health Psychol Rev 2020; https://doi.org/10.1080/17437199.2019.1709098
Hoffmann T. C., Glasziou P. P., Boutron I., Milne R., Perera R., Moher D., et al. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ 2014; 348: g1687.
Montgomery P., Grant S., Mayo-Wilson E., Macdonald G., Michie S., Hopewell S., et al. Reporting randomised trials of social and psychological interventions: the CONSORT-SPI 2018 extension. Trials 2018; 19: 407.
Pluye P., Robert E., Cargo M., Bartlett G., O'Cathain A., Griffiths F. et al Proposal: a mixed methods appraisal tool for systematic mixed studies reviews 2011. Available at: http://mixedmethodsappraisaltoolpublic.pbworks.com (accessed 28 August 2020).
Pace R., Pluye P., Bartlett G., Macaulay A. C., Salsberg J., Jagosh J., et al. Testing the reliability and efficiency of the pilot mixed methods appraisal tool (MMAT) for systematic mixed studies review. Int J Nurs Stud 2012; 49: 47-53.
Higgins J. P., Green S. Cochrane Handbook for Systematic Reviews of Interventions, version 5.1.0. 2011. Available at: handbook.cochrane.org (accessed 16 July 2020).
Higgins J. P. T., Thompson S. G., Deeks J. J., Altman D. G. Measuring inconsistency in meta-analyses. BMJ 2003; 327: 557-560.
West R. Assessing smoking cessation performance in NHS Stop Smoking Services: The Russell Standard (Clinical) University College London 2005. Available at: https://www.ncsct.co.uk/usr/pub/assessing-smoking-cessation-performance-in-nhs-stop-smoking-services-the-russell-standard-clinical.pdf (accessed 05 January 2021).
Peters J. L., Sutton A. J., Jones D. R., Abrams K. R., Rushton L. Comparison of two methods to detect publication bias in meta-analysis. JAMA 2006; 295: 676-680.
Lorencatto F., West R., Michie S. Specifying evidence-based behavior change techniques to aid smoking cessation in pregnancy. Nicotine Tob Res 2012; 14: 1019-1026.
Abroug H., El Hraiech A., Mehrez O., Ben Fredj M., Zemni I., Ben Salah A., et al. Acute coronary syndrome: factors predicting smoking cessation. East Mediterr Health J 2020; 26: 312-319.
Bernstein S. L., Weiss J., DeWitt M., Tetrault J. M., Hsiao A. L., Dziura J., et al. A randomized trial of decision support for tobacco dependence treatment in an inpatient electronic medical record: clinical results. Implement Sci 2019; 14: 8.
Campos A. C. F., Nani A. S. F., Fonseca V., Silva E. N., Castro M. C. S., Martins W. A. Comparison of two smoking cessation interventions for inpatients. J Bras Pneumol 2018; 44: 195-201.
Chui C. Y., Thomas D., Taylor S., Bonevski B., Abramson M. J., Paul E., et al. Factors associated with nicotine replacement therapy use among hospitalised smokers. Drug Alcohol Rev 2018; 37: 514-519.
Cruvinel E., Richter K. P., Colugnati F., Ronzani T. M. An experimental feasibility study of a hybrid telephone counseling/text messaging intervention for post-discharge cessation support among hospitalized smokers in Brazil. Nicotine Tob Res 2019; 21: 1700-1705.
Cummins S. E., Gamst A. C., Brandstein K., Seymann G. B., Klonoff-Cohen H., Kirby C. A., et al. Helping hospitalized smokers: a factorial RCT of nicotine patches and counseling. Am J Prev Med 2016; 51: 578-586.
Das S., Hickman N. J., Prochaska J. J. Treating smoking in adults with co-occurring acute psychiatric and addictive disorders. J Addict Med 2017; 11: 273-279.
Gariti P., Alterman A., Mulvaney F., Mechanic K., Dhopesh V., Yu E., et al. Nicotine intervention during detoxification and treatment for other substance use. Am J Drug Alcohol Abuse 2002; 28: 671-679.
Guillaumier A., Skelton E., Shakeshaft A., Farrell M., Tzelepis F., Walsberger S., et al. Effect of increasing the delivery of smoking cessation care in alcohol and other drug treatment centers: a cluster-randomized controlled trial. Addiction 2019; 115: 1345-1355.
Harrington K. F., Kim Y.-I., Chen M., Ramachandran R., Pisu M., Sadasivam R. S., et al. Web-based intervention for transitioning smokers from inpatient to outpatient care: an RCT. Am J Prev Med 2016; 51: 620-629.
Hickman N. J. III, Delucchi K. L., Prochaska J. J. Treating tobacco dependence at the intersection of diversity, poverty, and mental illness: a randomized feasibility and replication trial. Nicotine Tob Res 2015; 17: 1012-1021.
Metse A. P., Wiggers J., Wye P., Wolfenden L., Freund M., Clancy R., et al. Efficacy of a universal smoking cessation intervention initiated in inpatient psychiatry and continued post-discharge: a randomised controlled trial. Aust NZ J Psychiatry 2017; 51: 366-381.
Prochaska J. J., Hall S. E., Delucchi K., Hall S. M. Efficacy of initiating tobacco dependence treatment in inpatient psychiatry: a randomized controlled trial. Am J Public Health 2014; 104: 1557-1565.
Reid R. D., Aitken D. A., Mullen K. A., McDonnell L., Armstrong A., Leblanc A. G., et al. Automated telephone follow-up for smoking cessation in smokers with coronary heart disease: a randomized controlled trial. Nicotine Tobacco Res 2019; 21: 1051-1057.
Rigotti N. A., Regan S., Levy D. E., Japuntich S., Chang Y., Park E. R., et al. Sustained care intervention and postdischarge smoking cessation among hospitalized adults: a randomized clinical trial. JAMA 2014; 312: 719-728.
Rigotti N. A., Tindle H. A., Regan S., Levy D. E., Chang Y., Carpenter K. M., et al. A post-discharge smoking-cessation intervention for hospital patients: helping Hand 2 randomized clinical trial. Am J Prev Med 2016; 51: 597-608.
Steinberg M. B., Randall J., Greenhaus S., Schmelzer A. C., Richardson D. L., Carson J. L. Tobacco dependence treatment for hospitalized smokers: a randomized, controlled, pilot trial using varenicline. Addict Behav 2011; 36: 1127-1132.
Stockings E. A. L., Bowman J. A., Baker A. L., Terry M., Clancy R., Wye P. M., et al. Impact of a postdischarge smoking cessation intervention for smokers admitted to an inpatient psychiatric facility: a randomized controlled trial. Nicotine Tob Res 2014; 16: 1417-1428.
Streck J. M., Regan S., Chang Y., Kelley J. H. K., Singer D. E., Rigotti N. A. Examining the effects of illicit drug use on tobacco cessation outcomes in the helping HAND 2 randomized controlled trial. Drug Alcohol Depend 2017; 178: 586-592.
Thomas D., Abramson M. J., Bonevski B., Taylor S., Poole S. G., Paul E., et al. Integrating smoking cessation into routine care in hospitals-a randomized controlled trial. Addiction 2016; 111: 714-723.
Thorley R., Britton J., Nyakutsikwa B., Opazo Breton M., Lewis S. A., Murray R. L. Enhanced smoking cessation support for newly abstinent smokers discharged from hospital (the hospital to home trial): a randomized controlled trial. Addiction 2019; 114: 2037-2047.
Ylioja T., Cochran G., Chang Y., Tindle H. A., Rigotti N. A. Postdischarge smoking cessation in subgroups of hospitalized smokers: a latent class analysis. Subst Abuse 2017; 38: 493-497.
Duffy S. A., Noonan D., Karvonen-Gutierrez C. A., Ronis D. L., Ewing L. A., Waltje A. H., et al. Effectiveness of the tobacco tactics program for psychiatric inpatient veterans: an implementation study. Arch Psychiatr Nurs 2015; 29: 120-126.
Gies C. E., Buchman D., Robinson J., Smolen D. Effect of an inpatient nurse-directed smoking cessation program. West J Nurs Res 2008; 30: 6-19.
Politis A., Ioannidis V., Gourgoulianis K. I., Daniil Z., Hatzoglou C. Effects of varenicline therapy in combination with advanced behavioral support on smoking cessation and quality of life in inpatients with acute exacerbation of COPD, bronchial asthma, or community-acquired pneumonia: a prospective, open-label, preference-based, 52-week, follow-up trial. Chron Respir Dis 2018; 15: 146-156.
Bernard P., Ninot G., Cyprien F., Courtet P., Guillaume S., Georgescu V., et al. Exercise and counseling for smoking cessation in smokers with depressive symptoms: a randomized controlled pilot trial. J Dual Diagn 2015; 11: 205-216.
Guydish J., Ziedonis D., Tajima B., Seward G., Passalacqua E., Chan M., et al. Addressing tobacco through organizational change (ATTOC) in residential addiction treatment settings. Drug Alcohol Depend 2012; 121: 30-37.
Jonas J. M., Eagle J. Smoking patterns among patients discharged from a smoke-free inpatient unit. Psychiatr Serv 1991; 42: 636-637.
Joseph A. M. Nicotine treatment at the drug dependency program of the Minneapolis VA medical center: a researcher's perspective. J Subst Abuse Treat 1993; 10: 147-152.
Li V. W., Lam J., Heise P., Reid R. D., Mullen K. A. Implementation of a pharmacist-led inpatient tobacco cessation intervention in a rehabilitation hospital: a before-and-after pilot study. Can J Hosp Pharm 2018; 71: 180-186.
Strong D. R., Uebelacker L., Schonbrun Y. C., Durst A., Saritelli J., Fokas K., et al. Development of a brief motivational intervention to facilitate engagement of smoking cessation treatment among inpatient depressed smokers. J Smok Cessat 2012; 7: 4-11.
Stuyt E. B. Ear acupuncture for co-occurring substance abuse and borderline personality disorder: an aid to encourage treatment retention and tobacco cessation. Acupunct Med 2014; 32: 318-324.
Stuyt E. B. Enforced abstinence from tobacco during in-patient dual-diagnosis treatment improves substance abuse treatment outcomes in smokers. Am J Addict 2015; 24: 252-257.
van den Berg J. J., Bock B., Roberts M. B., Stein L. A., Friedmann P. D., Martin S. A., et al. Cigarette smoking as an expression of independence and freedom among inmates in a tobacco-free prison in the United States. Nicotine Tob Res 2014; 16: 238-242.
van den Berg J. J., Bock B. C., Roberts M. B., Parker D. R., Martin R. A., Stein L., et al. Goals and plans of incarcerated men postrelease. J Correct Health Care 2016; 22: 146-156.
Health CP. Population Health Methods: Meta-regression 2019. Available at: https://www.publichealth.columbia.edu/research/population-health-methods/meta-regression (accessed 08 September 2020).
McCrabb S., Baker A. L., Attia J., Skelton E., Twyman L., Palazzi K., et al. Internet-based programs incorporating behavior change techniques are associated with increased smoking cessation in the general population: a systematic review and meta-analysis. Ann Behav Med 2019; 53: 180-195.
Cane J., Richardson M., Johnston M., Ladha R., Michie S. From lists of behaviour change techniques (BCTs) to structured hierarchies: comparison of two methods of developing a hierarchy of BCTs. Br J Health Psychol 2015; 20: 130-150.
Campbell K. A., Fergie L., Coleman-Haynes T., Cooper S., Lorencatto F., Ussher M., et al. Improving behavioral support for smoking cessation in pregnancy: what are the barriers to stopping and which behavior change techniques can influence these? Application of theoretical domains framework. Int J Environ Res Public Health 2018; 15: 359.
Michie S., Johnston M. Encyclopaedia of Behavioral Medicine. In: Gellman M. D., Turner J. R., editors. Behaviour Change Techniques. New York: Springer; 2013, pp. 182-187. https://doi.org/10.1007/978-1-4419-1005-9_1661
Aschbrenner K. A., Naslund J. A., Gill L., Bartels S. J., O'Malley A., Brunette M. F. Preferences for smoking cessation support from family and friends among adults with serious mental illness. Psychiatric Q 2017; 88: 701-710.
Orton S., Coleman T., Coleman-Haynes T., Ussher M. Predictors of postpartum return to smoking: a systematic review. Nicotine Tob Res 2018; 20: 665-673.
Nguyen S., Von Kohorn I., Schulman-Green D., Colson E. The importance of social networks on smoking: perspectives of women who quit smoking during pregnancy. Matern Child Health J 2012; 16: 1312-1318.
Jackson S. E., McGowan J. A., Ubhi H. K., Proudfoot H., Shahab L., Brown J., et al. Modelling continuous abstinence rates over time from clinical trials of pharmacological interventions for smoking cessation. Addiction 2019; 114: 787-797.
McEwen A., Hajek P., McRobbie H., West R. Manual of Smoking Cessation: A Guide for Counsellors and Practitioners, 1st edn. Oxford, UK: Blackwell Publishing Ltd; 2006.
Michie S., Fixsen D., Grimshaw J. M., Eccles M. P. Specifying and reporting complex behaviour change interventions: the need for a scientific method. Implement Sci 2009; 4: 40.
Ainscough T. S., Mitchell A., Hewitt C., Horspool M., Stewart P., Ker S., et al. Investigating changes in patients' smoking behaviour, tobacco dependence and motivation to stop smoking following a ‘smoke-free’ mental health inpatient stay: results from a longitudinal survey in England. Nicotine Tob Res 2020; https://doi.org/10.1093/ntr/ntaa258
Ratschen E., Britton J., McNeill A. The smoking culture in psychiatry: time for change. Br J Psychiatry 2011; 198: 6-7.
Dallery J., Raiff B. R., Kim S. J., Marsch L. A., Stitzer M., Grabinski M. J. Nationwide access to an internet-based contingency management intervention to promote smoking cessation: a randomized controlled trial. Addiction 2017; 112: 875-883.
McClure E. A., Tomko R. L., Carpenter M. J., Treiber F. A., Gray K. M. Acceptability and compliance with a remote monitoring system to track smoking and abstinence among young smokers. Am J Drug Alcohol Abuse 2018; 44: 561-570.
Dahne J., Tomko R. L., McClure E. A., Obeid J. S., Carpenter M. J. Remote methods for conducting tobacco-focused clinical trials. Nicotine Tob Res 2020; 22: 2134-2140.
Herbec A., Brown J., Shahab L., West R. Lessons learned from unsuccessful use of personal carbon monoxide monitors to remotely assess abstinence in a pragmatic trial of a smartphone stop smoking app-a secondary analysis. Addict Behav Rep 2019; 9; https://doi.org/10.1016/j.abrep.2018.07.003
Crane D., Ubhi H. K., Brown J., West R. Relative effectiveness of a full versus reduced version of the ‘smoke free’ mobile application for smoking cessation: an exploratory randomised controlled trial [version 2; referees: 2 approved]. F1000Research 2019; 7: (no pagination)(1524).
Taylor G. M. J., Dalili M. N., Semwal M., Civljak M., Sheikh A., Car J. Internet-based interventions for smoking cessation. Cochrane Database Syst Rev 2017; 9: CD007078.