Prominent roles of ribosomal S6 kinase 4 (RSK4) in cancer.

Breast Neoplasms / genetics Colorectal Neoplasms / metabolism Esophageal Neoplasms / genetics Gene Expression Regulation, Neoplastic / genetics Humans Ribosomal Protein S6 Kinases / metabolism Ribosomal Protein S6 Kinases, 90-kDa / metabolism
Cancer Inhibitor Ribosomal S6 kinase 4 (RSK4)

Journal

Pathology, research and practice
ISSN: 1618-0631
Titre abrégé: Pathol Res Pract
Pays: Germany
ID NLM: 7806109

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 15 12 2020
revised: 05 02 2021
accepted: 08 02 2021
pubmed: 24 2 2021
medline: 4 11 2021
entrez: 23 2 2021
Statut: ppublish

Résumé

RSK4 refers to one Ser/Thr protein kinase functioning downstream pertaining to the signaling channel of protein kinase (MAPK) stimulated by Ras/mitogen. RSK4 can regulate numerous substrates impacting cells' surviving state, growing processes and proliferating process. Thus, dysregulated RSK4 active state display a relationship to several carcinoma categories, covering breast carcinoma, esophageal squamous cell carcinoma, glioma, colorectal carcinoma, lung carcinoma, ovarian carcinoma, leukemia, endometrial carcinoma, and kidney carcinoma. Whether RSK4 is a tumor suppressor gene or one oncogene remains controversial. No specific inhibiting elements for RSK4 have been found. This review briefs the existing information regarding RSK4 activating process, the function and mechanism of RSK4 in different tumors, and the research progress and limitations of existing RSK inhibitors. RSK4 may be a potential target of molecular therapy medicine in the future.

Identifiants

DOI: 10.1016/j.prp.2021.153374 PMID: 33621918
pubmed: 33621918
pii: S0344-0338(21)00035-2
doi: 10.1016/j.prp.2021.153374
pii:
doi:

Substances chimiques

RPS6KA6 protein, human EC 2.7.11.1
Ribosomal Protein S6 Kinases EC 2.7.11.1
Ribosomal Protein S6 Kinases, 90-kDa EC 2.7.11.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

153374

Informations de copyright

Copyright © 2021 Elsevier GmbH. All rights reserved.

Auteurs

Junpeng Xu (J)

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Qingge Jia (Q)

Xi'an International Medical Center, Northwest University, Xi'an, China.

Yan Zhang (Y)

Children's Heart Disease Center, Sichuan Maternal and Child Health Hospital, Chengdu, China.

Yuan Yuan (Y)

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Tianqi Xu (T)

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Kangjie Yu (K)

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Jia Chai (J)

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Kaijing Wang (K)

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.

Ligang Chen (L)

Department of Neurology, General Hospital of Northern Theater Command, Shenyang, China. Electronic address: clg201820271@126.com.

Tian Xiao (T)

State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Fourth Military Medical University, Xi'an, China. Electronic address: 397156543@qq.com.

Mingyang Li (M)

State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. Electronic address: limingyang1108@sina.com.

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Classifications MeSH

questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Prominent roles of ribosomal S6 kinase 4...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Prominent roles of ribosomal S6 kinase 4...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Tumeurs gastro-intestinales › Tumeurs de l'oesophage › Prominent roles of ribosomal S6 kinase 4...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Prominent roles of ribosomal S6 kinase 4...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prominent roles of ribosomal S6 kinase 4...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Ribosomal Protein S6 Kinases › Prominent roles of ribosomal S6 kinase 4...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Ribosomal Protein S6 Kinases › Ribosomal Protein S6 Kinases, 90-kDa › Prominent roles of ribosomal S6 kinase 4...