Fibril density reduction in keratoconic corneas.
cornea
keratoconus
ocular biomechanics
tissue microstructure
Journal
Journal of the Royal Society, Interface
ISSN: 1742-5662
Titre abrégé: J R Soc Interface
Pays: England
ID NLM: 101217269
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
entrez:
24
2
2021
pubmed:
25
2
2021
medline:
22
6
2021
Statut:
ppublish
Résumé
This study aims to estimate the reduction in collagen fibril density within the central 6 mm radius of keratoconic corneas through the processing of microstructure and videokeratography data. Collagen fibril distribution maps and topography maps were obtained for seven keratoconic and six healthy corneas, and topographic features were assessed to detect and calculate the area of the cone in each keratoconic eye. The reduction in collagen fibril density within the cone area was estimated with reference to the same region in the characteristic collagen fibril maps of healthy corneas. Together with minimum thickness and mean central corneal refractive power, the cone area was correlated with the reduction in the cone collagen fibrils. For the corneas considered, the mean area of keratoconic cones was 3.30 ± 1.90 mm
Identifiants
pubmed: 33622146
doi: 10.1098/rsif.2020.0900
pmc: PMC8086868
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20200900Subventions
Organisme : Medical Research Council
ID : MR/S037829/1
Pays : United Kingdom
Organisme : NEI NIH HHS
ID : R01 EY021500
Pays : United States
Organisme : Medical Research Council
ID : MR/K000837/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S037829/1
Pays : United Kingdom
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