Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.

Aged Ethnicity / genetics Humans Male Middle Aged Multifactorial Inheritance / genetics Multivariate Analysis Neoplasm Invasiveness Prostatic Neoplasms / genetics Self Report

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
23 02 2021
Historique:
received: 15 05 2020
accepted: 12 01 2021
entrez: 24 2 2021
pubmed: 25 2 2021
medline: 4 3 2021
Statut: epublish

Résumé

Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS

Identifiants

DOI: 10.1038/s41467-021-21287-0 PMID: 33623038 PMC: PMC7902617
pubmed: 33623038
doi: 10.1038/s41467-021-21287-0
pii: 10.1038/s41467-021-21287-0
pmc: PMC7902617
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1236

Subventions

Organisme : Cancer Research UK
ID : C18281/A8145
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C18281/A24432
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C18281/A15064
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C11043/A4286
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U10 CA037429
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA182883
Pays : United States
Organisme : NCI NIH HHS
ID : UG1 CA189974
Pays : United States
Organisme : NIBIB NIH HHS
ID : K08 EB026503
Pays : United States
Organisme : Cancer Research UK
ID : C18281/A11326
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C18281/A19169
Pays : United Kingdom

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Auteurs

Minh-Phuong Huynh-Le (MP)

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.
ORCID: 0000-0002-5025-4709

Chun Chieh Fan (CC)

Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.
ORCID: 0000-0001-9437-2128

Roshan Karunamuni (R)

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.

Wesley K Thompson (WK)

Division of Biostatistics and Halicioğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.
Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.

Maria Elena Martinez (ME)

Moores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.

Rosalind A Eeles (RA)

The Institute of Cancer Research, London, UK.
Royal Marsden NHS Foundation Trust, London, UK.
ORCID: 0000-0002-3698-6241

Zsofia Kote-Jarai (Z)

The Institute of Cancer Research, London, UK.

Kenneth Muir (K)

Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, UK.
Warwick Medical School, University of Warwick, Coventry, UK.
ORCID: 0000-0001-6429-988X

Johanna Schleutker (J)

Institute of Biomedicine, Kiinamyllynkatu 10, FI-20014 University of Turku, Turku, Finland.
Department of Medical Genetics, Genomics, Laboratory Division, Turku University Hospital, Turku, Finland.
ORCID: 0000-0002-1863-0305

Nora Pashayan (N)

University College London, Department of Applied Health Research, London, UK.
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge, UK.
Department of Applied Health Research, University College London, London, UK.
ORCID: 0000-0003-0843-2468

Jyotsna Batra (J)

Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Translational Research Institute, Brisbane, QLD, Australia.
ORCID: 0000-0003-4646-6247

Henrik Grönberg (H)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
ORCID: 0000-0002-1073-2753

David E Neal (DE)

Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.
Department of Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.

Jenny L Donovan (JL)

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Freddie C Hamdy (FC)

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Faculty of Medical Science, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Richard M Martin (RM)

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
National Institute for Health Research (NIHR) Biomedical Research Centre, University of Bristol, Bristol, UK.
Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
ORCID: 0000-0002-7992-7719

Sune F Nielsen (SF)

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Copenhagen, Denmark.

Børge G Nordestgaard (BG)

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Copenhagen, Denmark.
ORCID: 0000-0002-1954-7220

Fredrik Wiklund (F)

Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
ORCID: 0000-0002-4623-0544

Catherine M Tangen (CM)

SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
ORCID: 0000-0003-4946-9099

Alicja Wolk (A)

Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0001-7387-6845

Demetrius Albanes (D)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Ruth C Travis (RC)

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0002-9571-0763

William J Blot (WJ)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
International Epidemiology Institute, Rockville, MD, USA.

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0003-1226-070X

Maureen Sanderson (M)

Department of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA.

Janet L Stanford (JL)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.

Lorelei A Mucci (LA)

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Catharine M L West (CML)

Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK.
ORCID: 0000-0002-0839-3449

Adam S Kibel (AS)

Division of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA.

Olivier Cussenot (O)

Sorbonne Universite, GRC n°5, AP-HP, Tenon Hospital, 4 Rue de la Chine, Paris, France.
CeRePP, Tenon Hospital, Paris, France.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Stella Koutros (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.

Karina Dalsgaard Sørensen (KD)

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
ORCID: 0000-0002-4902-5490

Cezary Cybulski (C)

International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

Eli Marie Grindedal (EM)

Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.

Florence Menegaux (F)

Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif Cédex, France.
Paris-Sud University, UMRS 1018, Villejuif Cedex, France.

Kay-Tee Khaw (KT)

Clinical Gerontology Unit, University of Cambridge, Cambridge, UK.

Jong Y Park (JY)

Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
ORCID: 0000-0002-6384-6447

Sue A Ingles (SA)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.

Christiane Maier (C)

Humangenetik Tuebingen, Tuebingen, Germany.

Robert J Hamilton (RJ)

Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Department of Surgery (Urology), University of Toronto, Toronto, ON, Canada.

Stephen N Thibodeau (SN)

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Barry S Rosenstein (BS)

Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Yong-Jie Lu (YJ)

Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.

Stephen Watya (S)

Uro Care, Kampala, Uganda.

Ana Vega (A)

Fundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago De Compostela, Spain.
Centro de Investigación en Red de Enfermedades Raras (CIBERER), Santiago De Compostela, Spain.
ORCID: 0000-0002-7416-5137

Manolis Kogevinas (M)

ISGlobal, Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Kathryn L Penney (KL)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.

Chad Huff (C)

The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Manuel R Teixeira (MR)

Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
ORCID: 0000-0002-4896-5982

Luc Multigner (L)

Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, Rennes, France.
ORCID: 0000-0003-3205-8568

Robin J Leach (RJ)

Department of Urology, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Lisa Cannon-Albright (L)

Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA.
ORCID: 0000-0003-2602-3668

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 460, Heidelberg, Germany.

Esther M John (EM)

Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Radka Kaneva (R)

Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.

Christopher J Logothetis (CJ)

The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX, USA.

Susan L Neuhausen (SL)

Department of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

Kim De Ruyck (K)

Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Gent, Belgium.

Hardev Pandha (H)

The University of Surrey, Guildford, Surrey, UK.

Azad Razack (A)

Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Lisa F Newcomb (LF)

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Department of Urology, University of Washington, Seattle, WA, USA.

Jay H Fowke (JH)

Department of Medicine and Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Division of Epidemiology, Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA.

Marija Gamulin (M)

Department of Oncology, University Hospital Centre Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.
ORCID: 0000-0003-2431-7910

Nawaid Usmani (N)

Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Division of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.

Frank Claessens (F)

Department of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, KU Leuven, Leuven, Belgium.

Manuela Gago-Dominguez (M)

Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.
University of California San Diego, Moores Cancer Center, La Jolla, CA, USA.

Paul A Townsend (PA)

Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK.

William S Bush (WS)

Case Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Cleveland, OH, USA.
ORCID: 0000-0002-9729-6519

Monique J Roobol (MJ)

Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.
ORCID: 0000-0001-6967-1708

Marie-Élise Parent (MÉ)

Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, QC, Canada.

Jennifer J Hu (JJ)

The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.

Ian G Mills (IG)

Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.

Ole A Andreassen (OA)

NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.
ORCID: 0000-0002-4461-3568

Anders M Dale (AM)

Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.
Department of Radiology, University of California San Diego, La Jolla, CA, USA.

Tyler M Seibert (TM)

Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA. tseibert@ucsd.edu.
Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA. tseibert@ucsd.edu.
Department of Radiology, University of California San Diego, La Jolla, CA, USA. tseibert@ucsd.edu.
Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. tseibert@ucsd.edu.
ORCID: 0000-0002-4089-7399

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Polygenic hazard score is associated with...
questionsmedicales.fr › Caractéristiques de la population › Ethnies › Polygenic hazard score is associated with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Polygenic hazard score is associated with...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Polygenic hazard score is associated with...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Polygenic hazard score is associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de variance › Analyse multifactorielle › Polygenic hazard score is associated with...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › Polygenic hazard score is associated with...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Polygenic hazard score is associated with...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Autorapport › Polygenic hazard score is associated with...