A poly-ADP-ribose polymer-based antibody-drug conjugate.


Journal

Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951

Informations de publication

Date de publication:
14 Sep 2020
Historique:
received: 28 03 2020
accepted: 13 08 2020
entrez: 24 2 2021
pubmed: 25 2 2021
medline: 25 2 2021
Statut: epublish

Résumé

Protein poly-ADP-ribosylation (PARylation) plays vital roles in many aspects of physiology and pathophysiology. This posttranslational modification is catalyzed by poly-ADP-ribose polymerases (PARPs) through additions of ADP-ribose from nicotinamide adenine dinucleotide (NAD

Identifiants

pubmed: 33623656
doi: 10.1039/d0sc01795g
pii: d0sc01795g
pmc: PMC7871713
doi:

Types de publication

Journal Article

Langues

eng

Pagination

9303-9308

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK048522
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM137901
Pays : United States

Informations de copyright

This journal is © The Royal Society of Chemistry 2020.

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Auteurs

Xiaojing Shi (X)

Department of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA.

Xiao-Nan Zhang (XN)

Department of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA.

Jingwen Chen (J)

Department of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA.

Qinqin Cheng (Q)

Department of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA.

Hua Pei (H)

Titus Family Department of Clinical Pharmacy , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA.

Stan G Louie (SG)

Titus Family Department of Clinical Pharmacy , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA.

Yong Zhang (Y)

Department of Pharmacology and Pharmaceutical Sciences , School of Pharmacy , University of Southern California , Los Angeles , CA 90089 , USA.
Department of Chemistry , Dornsife College of Letters , Arts and Sciences , University of Southern California , Los Angeles , CA 90089 , USA.
Norris Comprehensive Cancer Center , University of Southern California , Los Angeles , CA 90089 , USA.
Research Center for Liver Diseases , University of Southern California , Los Angeles , CA 90089 , USA . Email: yongz@usc.edu.

Classifications MeSH