Oncogenic mechanisms in renal insufficiency.
cancer
carcinogenesis
end-stage renal disease
malignancy
renal transplant
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
08
12
2019
accepted:
08
05
2020
entrez:
24
2
2021
pubmed:
25
2
2021
medline:
25
2
2021
Statut:
epublish
Résumé
The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin-angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.
Identifiants
pubmed: 33623673
doi: 10.1093/ckj/sfaa122
pii: sfaa122
pmc: PMC7886561
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
507-515Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of ERA-EDTA.
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