Resident Macrophages in Cystic Kidney Disease.
Journal
Kidney360
ISSN: 2641-7650
Titre abrégé: Kidney360
Pays: United States
ID NLM: 101766381
Informations de publication
Date de publication:
28 01 2021
28 01 2021
Historique:
entrez:
24
2
2021
pubmed:
25
2
2021
medline:
25
2
2021
Statut:
ppublish
Résumé
Interstitial inflammation is an important feature of cystic kidney disease. Renal macrophages are the most well-studied inflammatory cell in the kidney, and their involvement in cyst formation has been reported in different animal models and patients with cystic kidney disease. Originally, it was believed that renal macrophages were maintained from a constant supply of bone marrow-derived circulating monocytes, and could be recruited to the kidney in response to local inflammation. However, this idea has been challenged using fate-mapping methods, by showing that at least two distinct developmental origins of macrophages are present in the adult mouse kidney. The first type, infiltrating macrophages, are recruited from circulating monocytes and gradually develop macrophage properties on entering the kidney. The second, resident macrophages, predominantly originate from embryonic precursors, colonize the kidney during its development, and proliferate
Identifiants
pubmed: 33623927
doi: 10.34067/KID.0006052020
pmc: PMC7899042
mid: NIHMS1667979
pii: 02200512-202101000-00023
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Pagination
167-175Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM134973
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007051
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK090868
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK074038
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK126114
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK119375
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115752
Pays : United States
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