Protein S-Palmitoylation: advances and challenges in studying a therapeutically important lipid modification.
lipidation
membranes
palmitoyl-acyl transferase
post-translational modification
thioesterase
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
01
02
2021
received:
06
12
2020
accepted:
22
02
2021
pubmed:
25
2
2021
medline:
3
3
2022
entrez:
24
2
2021
Statut:
ppublish
Résumé
The lipid post-translational modification S-palmitoylation is a vast developing field, with the modification itself and the enzymes that catalyse the reversible reaction implicated in a number of diseases. In this review, we discuss the past and recent advances in the experimental tools used in this field, including pharmacological tools, animal models and techniques to understand how palmitoylation controls protein localisation and function. Additionally, we discuss the obstacles to overcome in order to advance the field, particularly to the point at which modulating palmitoylation may be achieved as a therapeutic strategy.
Substances chimiques
Lipids
0
Protein S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
861-882Subventions
Organisme : British Heart Foundation
ID : RE/18/6/34217
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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