Tumour angiogenesis normalized by myo-inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response.

Animals Antineoplastic Agents / pharmacology B7-H1 Antigen / metabolism Cell Hypoxia Cell Line, Tumor Inositol Phosphates / pharmacology Lymphocytes / drug effects Macrophages / drug effects Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Neovascularization, Pathologic / drug therapy PTEN Phosphohydrolase / metabolism Programmed Cell Death 1 Ligand 2 Protein / metabolism Tumor Cells, Cultured Tumor Microenvironment
angiogenesis cancer hypoxia immune response microenvironment myo-inositol trispyrophosphate oxygen partial pressure (pO2) vessel normalization

Journal

Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777

Informations de publication

Date de publication:
04 2021
Historique:
revised: 02 02 2021
received: 06 11 2020
accepted: 05 02 2021
pubmed: 25 2 2021
medline: 18 9 2021
entrez: 24 2 2021
Statut: ppublish

Résumé

Pathologic angiogenesis directly responds to tumour hypoxia and controls the molecular/cellular composition of the tumour microenvironment, increasing both immune tolerance and stromal cooperation with tumour growth. Myo-inositol-trispyrophosphate (ITPP) provides a means to achieve stable normalization of angiogenesis. ITPP increases intratumour oxygen tension (pO

Identifiants

DOI: 10.1111/jcmm.16399 PMID: 33624446 PMC: PMC8034441
pubmed: 33624446
doi: 10.1111/jcmm.16399
pmc: PMC8034441
doi:

Substances chimiques

Antineoplastic Agents 0
B7-H1 Antigen 0
Inositol Phosphates 0
Programmed Cell Death 1 Ligand 2 Protein 0
inositol trispyrophosphate 0
PTEN Phosphohydrolase EC 3.1.3.67

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3284-3299

Subventions

Organisme : Polish Ministry of Defense
ID : 579/2016/DA
Organisme : National Scientific Center, Poland
ID : 2016/23/B/NZ1/03211
Organisme : National Scientific Center, Poland
ID : 016/23/B/NZ6/02542
Organisme : Polish Ministry of Science and Higher Education
ID : 347/N-INCA/2008/0
Organisme : CNRS
Organisme : Region Centre ACI
Organisme : Normoxys Inc

Informations de copyright

© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

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Auteurs

Bouchra El Hafny-Rahbi (B)

Centre for Molecular Biophysics, UPR CNRS 4301, Orléans CEDEX 2, France.

Klaudia Brodaczewska (K)

Laboratory of Molecular Oncology and Innovative Therapies, WIM, Warsaw, Poland.

Guillaume Collet (G)

Centre for Molecular Biophysics, UPR CNRS 4301, Orléans CEDEX 2, France.

Aleksandra Majewska (A)

Laboratory of Molecular Oncology and Innovative Therapies, WIM, Warsaw, Poland.
Postgraduate School of Molecular Medicine (SMM), Warsaw Medical University, Warsaw, Poland.

Krzysztof Klimkiewicz (K)

Centre for Molecular Biophysics, UPR CNRS 4301, Orléans CEDEX 2, France.
Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.

Anthony Delalande (A)

Centre for Molecular Biophysics, UPR CNRS 4301, Orléans CEDEX 2, France.

Catherine Grillon (C)

Centre for Molecular Biophysics, UPR CNRS 4301, Orléans CEDEX 2, France.

Claudine Kieda (C)

Centre for Molecular Biophysics, UPR CNRS 4301, Orléans CEDEX 2, France.
Laboratory of Molecular Oncology and Innovative Therapies, WIM, Warsaw, Poland.
ORCID: 0000-0002-7573-029X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Glucides › Oses phosphates › Inositol phosphates › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Phosphohydrolase PTEN › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Ligand-2 de la protéine-1 de mort cellulaire programmée › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Tumour angiogenesis normalized by myo-inositol...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Tumour angiogenesis normalized by myo-inositol...