Design of Perfused PTFE Vessel-Like Constructs for In Vitro Applications.
Bioreactors
Blood Vessel Prosthesis
Carbon
/ chemistry
Cell Adhesion
Cell Line
Dendrimers
/ chemistry
Dimethylpolysiloxanes
/ chemistry
Endothelial Cells
Fluorescent Dyes
/ chemistry
Humans
In Vitro Techniques
Microscopy, Electron, Scanning
Nanotubes, Carbon
/ chemistry
Perfusion
Polytetrafluoroethylene
/ chemistry
Prosthesis Design
Quantum Dots
Stress, Mechanical
Tensile Strength
Tissue Engineering
/ methods
PTFE
endothelial cells
perfusion bioreactor
Journal
Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
13
01
2021
pubmed:
25
2
2021
medline:
21
12
2021
entrez:
24
2
2021
Statut:
ppublish
Résumé
Tissue models mimic the complex 3D structure of human tissues, which allows the study of pathologies and the development of new therapeutic strategies. The introduction of perfusion overcomes the diffusion limitation and enables the formation of larger tissue constructs. Furthermore, it provides the possibility to investigate the effects of hematogenously administered medications. In this study, the applicability of hydrophilic polytetrafluoroethylene (PTFE) membranes as vessel-like constructs for further use in perfused tissue models is evaluated. The presented approach allows the formation of stable and leakproof tubes with a mean diameter of 654.7 µm and a wall thickness of 84.2 µm. A polydimethylsiloxane (PDMS) chip acts as a perfusion bioreactor and provides sterile conditions. As proof of concept, endothelial cells adhere to the tube's wall, express vascular endothelial cadherin (VE-cadherin) between neighboring cells, and resist perfusion at a shear rate of 0.036 N m
Identifiants
pubmed: 33624920
doi: 10.1002/mabi.202100016
doi:
Substances chimiques
Dendrimers
0
Dimethylpolysiloxanes
0
Fluorescent Dyes
0
Nanotubes, Carbon
0
baysilon
63148-62-9
Carbon
7440-44-0
Polytetrafluoroethylene
9002-84-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2100016Informations de copyright
© 2021 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.
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