Prevalence of Otological Disease in Turner Syndrome: A Systematic Review.
Journal
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
ISSN: 1537-4505
Titre abrégé: Otol Neurotol
Pays: United States
ID NLM: 100961504
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
pubmed:
25
2
2021
medline:
27
7
2021
entrez:
24
2
2021
Statut:
ppublish
Résumé
Girls and women with Turner syndrome (TS) present with multiple ear and hearing problems, ranging from external morphologic abnormalities to sensorineural or conductive hearing loss. The exact pathophysiology behind these otological diseases is not yet completely understood. The aim of this study is to provide a systematic review on the prevalence of otological disease in TS. We conducted a systematic review according to the PRISMA guidelines. A database search was performed in PubMed, Embase, Web of Science, and Cochrane library. The prevalence of otological disease as external ear deformities (20-62%), recurrent otitis media (24-48%), and hearing loss (36-84%) is high in TS. The auditory phenotype in TS is complex and seems to be dynamic with CHL due to middle ear disease at young age and sensorineural hearing loss later in life. This systematic review of the literature confirms that otological disease is definitely part of the widely variable phenotype in Turner patients. Strong evidence is lacking on the exact prevalence numbers, emphasizing the need for more prospective data gathering. Growing insights in its pathophysiology will help in the understanding and management of hearing problems in TS across lifespan.
Identifiants
pubmed: 33625195
doi: 10.1097/MAO.0000000000003118
pii: 00129492-202108000-00001
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
953-958Informations de copyright
Copyright © 2021, Otology & Neurotology, Inc.
Déclaration de conflit d'intérêts
The authors disclose no conflicts of interest.
Références
Ranke MB, Saenger P. Turner's syndrome. Lancet 2001; 358:309–314.
Verver EJJ, Freriks K, Thomeer HGXM, et al. Ear and hearing problems in relation to karyotype in children with Turner syndrome. Hear Res 2011; 275:81–88.
Turner HH. A syndrome of infantilism, congenital webbed neck, and cubitus valgus. Endocrinology 1938; 23:566–574.
Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009; 6:e1000097.
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev 2016; 5:1–11.
Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C. Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and incidence data. Int J Evid based Healthc 2015; 13:147–153.
McMaster University (developed by Evidence Prime Inc) X. GRADEpro GDT: GRADEpro Guideline Development Tool. Available at gradepro.org. Published 2020.
Makishima T, King K, Brewer CC, et al. Otolaryngologic markers for the early diagnosis of Turner syndrome. Int J Pediatr Otorhinolaryngol 2009; 73:1564–1567.
Barrenas M, Landin-Wilhelmsen K, Hanson C. Ear and hearing in relation to genotype and growth in Turner syndrome. Hear Res 2000; 144:21–28.
Dhooge IJM, De Vel E, Verhoye C, Lemmerling M, Vinck B. Otologic disease in Turner syndrome. Otol Neurotol 2005; 26:145–150.
Chan KC, Wang PC, Wu CM, et al. Otologic and audiologic features of ethnic Chinese patients with Turner syndrome in Taiwan. J Formos Med Assoc 2012; 111:94–100.
Alvarez-Nava F, Racines-Orbe M, Witt J, et al. Metabolic syndrome as a risk factor for sensorineural hearing loss in adult patients with turner syndrome. Appl Clin Genet 2020; 13:25–35.
Hultcrantz M. Ear and hearing problems in Turner syndrome. Acta Otolaryngol 2003; 123:253–257.
Bergamaschi R, Bergonzoni C, Mazzanti L, et al. Hearing loss in Turner syndrome: Results of a multicentric study. J Endocrinol Invest 2008; 31:779–783.
Bois E, Nassar M, Zenaty D, Leger J, Van Den Abbeele T, Teissier N. Otologic disorders in Turner syndrome. Eur Ann Otorhinolaryngol Head Neck Dis 2018; 135:21–24.
Gawron W, Wikiera B, Rostkowska-Nadolska B, Orendorz-Fraczkowska K, Noczyńska A. Evaluation of hearing organ in patients with Turner syndrome. Int J Pediatr Otorhinolaryngol 2008; 72:575–579.
Lim DBN, Gault EJ, Kubba H, Morrissey MSC, Wynne DM, Donaldson MDC. Cholesteatoma has a high prevalence in Turner syndrome, highlighting the need for earlier diagnosis and the potential benefits of otoscopy training for paediatricians. Acta Paediatr 2014; 103:282–287.
Hamberis AO, Mehta CH, Dornhoffer JR, Meyer TA. Characteristics and progression of hearing loss in children with turner's syndrome. Laryngoscope 2019; 130:1540–1546.
Ostberg JE, Beckman A, Cadge B, Conway GS. Oestrogen deficiency and growth hormone treatment in childhood are not associated with hearing in adults with turner syndrome. Horm Res 2004; 62:182–186.
Beckman A, Conway GS, Cadge B. Audiological features of Turner's syndrome in adults. Int J Audiol 2004; 43:533–544.
Bonnard A, Hederstierna C, Bark R, et al. Audiometric features in young adults with Turner syndrome. Int J Audiol 2017; 56:650–656.
Han TS, Cadge B, Conway GS. Hearing impairment and low bone mineral density increase the risk of bone fractures in women with Turner's syndrome. Clin Endocrinol (Oxf) 2006; 65:643–647.
Anderson H, Filipsson R, Fluur E, Koch B, Lindsten J, Wedenberg E. Hearing impairment in Turner's syndrome. Acta Otolaryngol 1969; suppl 247:1–26.
King KA, Makishima T, Zalewski CK, et al. Analysis of auditory phenotype and karyotype in 200 females with Turner syndrome. Ear Hear 2007; 28:831–841.
Hederstierna C, Hultcrantz M, Rosenhall U. A longitudinal study of hearing decline in women with Turner syndrome. Acta Otolaryngol 2009; 129:1434–1441.
Fiot E, Zenaty D, Boizeau P, et al. X chromosome gene dosage as a determinant of congenital malformations and of age-related comorbidity risk in patients with Turner syndrome, from childhood to early adulthood. Eur J Endocrinol 2019; 180:397–406.
Clement-Jones M, Schiller S, Rao E, et al. The short stature homeobox SHOX is involved in skeletal abnormalities in Turner syndrome. Hum Mol Genet 2000; 9:695–702.
Paton GR, Silver MF, Allison AC. Comparison of cell cycle time in normal and trisomic cells. Humangenetik 1974; 23:173–182.
Selikowitz M. Health problems and health checks in school-aged children with Down syndrome. J Paediatr Child Health 1992; 28:383–386.