Elevated methaemoglobin in a critically ill patient as a result of hydrogen peroxide exposure: A case study.
MetHb
acetone
hydrogen peroxide
toxicology
Journal
Journal of clinical pharmacy and therapeutics
ISSN: 1365-2710
Titre abrégé: J Clin Pharm Ther
Pays: England
ID NLM: 8704308
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
revised:
08
02
2021
received:
03
02
2021
accepted:
10
02
2021
pubmed:
25
2
2021
medline:
12
1
2022
entrez:
24
2
2021
Statut:
ppublish
Résumé
Formation of methaemoglobinaemia (MetHb) decreases oxygen capacity in the blood, leading to tissue hypoxia. This condition may be acquired following exposure to certain drugs. A critically ill patient with necrotizing fasciitis unexpectedly developed marked and unexplained MetHb (6.7%). Her digital medication list did not reveal the causative factor. However, deeper exploration showed the use of other compounds (acetone, hydrogen peroxide) not routinely visible on the medication list. Elevated MetHb likely resulted from high-volume hydrogen peroxide 3% exposure. Clinicians should be cautious rinsing large open wounds with hydrogen peroxide. When MetHb is diagnosed, less familiar compounds, usually not on the medication list, should be considered in the differential diagnosis and extensive hetero-anamnesis is mandatory.
Substances chimiques
Hydrogen Peroxide
BBX060AN9V
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1473-1475Informations de copyright
© 2021 John Wiley & Sons Ltd.
Références
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