Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis.
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
23 02 2021
23 02 2021
Historique:
received:
27
07
2020
revised:
18
11
2020
accepted:
02
02
2021
entrez:
24
2
2021
pubmed:
25
2
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
Morphological plasticity is a key virulence trait for many fungal pathogens. For the opportunistic fungal pathogen Candida albicans, transitions among yeast, pseudohyphal, and hyphal forms are critical for virulence, because the morphotypes play distinct roles in the infection process. C. albicans morphogenesis is induced in response to many host-relevant conditions and is regulated by complex signaling pathways and cellular processes. Perturbation of either cell-cycle progression or protein homeostasis induces C. albicans filamentation, demonstrating that these processes play a key role in morphogenetic control. Regulators such as cyclin-dependent kinases, checkpoint proteins, the proteasome, the heat shock protein Hsp90, and the heat shock transcription factor Hsf1 all influence morphogenesis, often through interconnected effects on the cell cycle and proteostasis. This review highlights the major cell-cycle and proteostasis regulators that modulate morphogenesis and discusses how these two processes intersect to regulate this key virulence trait.
Identifiants
pubmed: 33626353
pii: S2211-1247(21)00094-2
doi: 10.1016/j.celrep.2021.108781
pmc: PMC7971348
mid: NIHMS1677112
pii:
doi:
Substances chimiques
Cell Cycle Proteins
0
Fungal Proteins
0
HSP90 Heat-Shock Proteins
0
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108781Subventions
Organisme : NIAID NIH HHS
ID : R01 AI127375
Pays : United States
Organisme : CIHR
ID : FDN-154288
Pays : Canada
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests L.E.C. is a cofounder and shareholder in Bright Angel Therapeutics, a platform company for development of novel antifungal therapeutics. L.E.C. is also a consultant for Boragen, a small-molecule development company focused on leveraging the unique chemical properties of boron chemistry for crop protection and animal health.
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