Pancreas preservation time as a predictor of prolonged hospital stay after pancreas transplantation.
Pancreas transplant
hospital stay
pancreas preservation time
patient outcome
short-term prognosis
survival
Journal
The Journal of international medical research
ISSN: 1473-2300
Titre abrégé: J Int Med Res
Pays: England
ID NLM: 0346411
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
Length of hospital stay is a sensitive indicator of short-term prognosis. In this retrospective study, we investigated how pancreas preservation time affects length of hospital stay after pancreas transplantation. Patients receiving pancreas transplantation (1998.7-2018.6) were identified from the Scientific Registry of Transplant Recipients database and grouped according to pancreas preservation time. We analyzed the relationship of pancreas preservation time with graft and patient survival and prolonged length of stay (PLOS; i.e., hospital stay ≥20 days). We included 18,099 pancreas transplants in the survival analysis. Pancreas preservation time >20 hours had a significantly higher risk of graft failure than 8 to 12 hours. Pancreas preservation time was not significantly associated with patient survival. We included 17,567 pancreas transplants in the analysis for PLOS. Compared with 8 to 12 hours, pancreas preservation time >12 hours had a significantly higher PLOS risk, which increased with increased pancreas preservation time. In simultaneous pancreas-kidney transplantation, we also found that pancreas preservation time was positively associated with PLOS risk with pancreas preservation time >12 hours. Pancreas preservation time is a sensitive predictor of PLOS. Transplant centers should minimize pancreas preservation time to optimize patient outcomes.
Identifiants
pubmed: 33626941
doi: 10.1177/0300060520987059
pmc: PMC7925952
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
300060520987059Références
Surgery. 1967 Jun;61(6):827-37
pubmed: 5338113
Rev Diabet Stud. 2011 Spring;8(1):6-16
pubmed: 21720668
Clin Transplant. 2005 Aug;19(4):433-55
pubmed: 16008587
Am J Transplant. 2006;6(5 Pt 2):1228-42
pubmed: 16613598
Health Econ. 2003 Nov;12(11):935-47
pubmed: 14601156
Transpl Int. 2015 Sep;28(9):1028-33
pubmed: 25789920
Transplantation. 2017 Nov;101(11):2757-2764
pubmed: 28099402
Transplant Proc. 2008 Jun;40(5):1275-8
pubmed: 18589086
Transplantation. 1997 Dec 27;64(12):1637-41
pubmed: 9422394
Clin Transplant. 2017 Sep;31(9):
pubmed: 28636074
Ann Surg. 1999 Aug;230(2):251-9
pubmed: 10450740
Transplantation. 2020 Mar;104(3):623-631
pubmed: 31335772
Nat Rev Endocrinol. 2013 Sep;9(9):555-62
pubmed: 23897173
Transplantation. 2001 Sep 27;72(6):1103-7
pubmed: 11579308
Am J Med Qual. 1995 Spring;10(1):48-54
pubmed: 7727988
Curr Opin Organ Transplant. 2013 Feb;18(1):83-8
pubmed: 23254698
Clin Transplant. 2015 Dec;29(12):1195-202
pubmed: 26447760
J Gen Intern Med. 2006 Feb;21(2):177-80
pubmed: 16606377
Transplantation. 2004 Oct 27;78(8):1188-92
pubmed: 15502718
Am J Transplant. 2004 Dec;4(12):2018-26
pubmed: 15575904
Curr Opin Organ Transplant. 2010 Feb;15(1):112-8
pubmed: 20009931
Am J Transplant. 2003 Nov;3(11):1440-3
pubmed: 14525607
Am J Surg. 1992 Nov;164(5):546-51
pubmed: 1443386
Int J Qual Health Care. 2004 Feb;16(1):51-7
pubmed: 15020560
Surgery. 2000 May;127(5):545-51
pubmed: 10819063
JAMA. 2003 Oct 8;290(14):1868-74
pubmed: 14532315
Am J Transplant. 2010 Apr;10(4):837-45
pubmed: 20121753
Lancet. 2009 May 23;373(9677):1808-17
pubmed: 19465236