Cerebellar transcranial direct current stimulation reconfigurates static and dynamic functional connectivity of the resting-state networks.
Cerebellum
Default-mode network
Dynamics
Functional connectivity
Limbic network
Resting-state
Salience network
Transcranial direct stimulation
Journal
Cerebellum & ataxias
ISSN: 2053-8871
Titre abrégé: Cerebellum Ataxias
Pays: England
ID NLM: 101648460
Informations de publication
Date de publication:
24 Feb 2021
24 Feb 2021
Historique:
received:
30
10
2020
accepted:
16
02
2021
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
26
2
2021
Statut:
epublish
Résumé
Transcranial direct current stimulation (tDCS) of the cerebellum dynamically modulates cerebello-thalamo-cortical excitability in a polarity-specific manner during motor, visuo- motor and cognitive tasks. It remains to be established whether tDCS of the cerebellum impact also on resting-state intrinsically connected networks (ICNs). Such impact would open novel research and therapeutical doors for the neuromodulation of ICNs in human. We combined tDCS applied over the right cerebellum and fMRI to investigate tDCS- induced resting-state intrinsic functional reconfiguration, using a randomized, sham-controlled design. fMRI data were recorded both before and after real anodal stimulation (2 mA, 20 min) or sham tDCS in 12 right-handed healthy volunteers. We resorted to a region-of-interest static correlational analysis and to a sliding window analysis to assess temporal variations in resting state FC between the cerebellar lobule VII and nodes of the main ICNs. After real tDCS and compared with sham tDCS, functional changes were observed between the cerebellum and ICNs. Static FC showed enhanced or decreased correlation between cerebellum and brain areas belonging to visual, default-mode (DMN), sensorimotor and salience networks (SN) (p-corrected < 0.05). The temporal variability (TV) of BOLD signal was significantly modified after tDCS displaying in particular a lesser TV between the whole lobule VII and DMN and central executive network and a greater TV between crus 2 and SN. Static and dynamic FC was also modified between cerebellar lobuli. These results demonstrate short- and long-range static and majorly dynamic effects of tDCS stimulation of the cerebellum affecting distinct resting-state ICNs, as well as intracerebellar functional connectivity, so that tDCS of the cerebellum appears as a non-invasive tool reconfigurating the dynamics of ICNs.
Sections du résumé
BACKGROUND
BACKGROUND
Transcranial direct current stimulation (tDCS) of the cerebellum dynamically modulates cerebello-thalamo-cortical excitability in a polarity-specific manner during motor, visuo- motor and cognitive tasks. It remains to be established whether tDCS of the cerebellum impact also on resting-state intrinsically connected networks (ICNs). Such impact would open novel research and therapeutical doors for the neuromodulation of ICNs in human.
METHOD
METHODS
We combined tDCS applied over the right cerebellum and fMRI to investigate tDCS- induced resting-state intrinsic functional reconfiguration, using a randomized, sham-controlled design. fMRI data were recorded both before and after real anodal stimulation (2 mA, 20 min) or sham tDCS in 12 right-handed healthy volunteers. We resorted to a region-of-interest static correlational analysis and to a sliding window analysis to assess temporal variations in resting state FC between the cerebellar lobule VII and nodes of the main ICNs.
RESULTS
RESULTS
After real tDCS and compared with sham tDCS, functional changes were observed between the cerebellum and ICNs. Static FC showed enhanced or decreased correlation between cerebellum and brain areas belonging to visual, default-mode (DMN), sensorimotor and salience networks (SN) (p-corrected < 0.05). The temporal variability (TV) of BOLD signal was significantly modified after tDCS displaying in particular a lesser TV between the whole lobule VII and DMN and central executive network and a greater TV between crus 2 and SN. Static and dynamic FC was also modified between cerebellar lobuli.
CONCLUSION
CONCLUSIONS
These results demonstrate short- and long-range static and majorly dynamic effects of tDCS stimulation of the cerebellum affecting distinct resting-state ICNs, as well as intracerebellar functional connectivity, so that tDCS of the cerebellum appears as a non-invasive tool reconfigurating the dynamics of ICNs.
Identifiants
pubmed: 33627197
doi: 10.1186/s40673-021-00132-6
pii: 10.1186/s40673-021-00132-6
pmc: PMC7905591
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7Références
Curr Biol. 2018 Nov 5;28(21):3364-3372.e5
pubmed: 30344119
Brain Res. 2015 Jan 12;1594:92-107
pubmed: 25312829
Neurosci Biobehav Rev. 2013 Jun;37(5):766-89
pubmed: 23500608
Cerebellum. 2015 Feb;14(1):27-30
pubmed: 25231432
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
J Neurosci. 2003 Sep 10;23(23):8432-44
pubmed: 12968006
Neuroreport. 2004 Jun 7;15(8):1307-10
pubmed: 15167555
Neuroimage. 2010 Feb 1;49(3):2045-52
pubmed: 19857577
Neuroscientist. 2011 Feb;17(1):37-53
pubmed: 21343407
Neuropsychopharmacology. 2016 Jun;41(7):1822-30
pubmed: 26632990
Cereb Cortex. 2010 Apr;20(4):953-65
pubmed: 19684249
Neuroimage. 2015 Jan 1;104:430-6
pubmed: 25234118
Neuroimage. 2011 Mar 1;55(1):8-23
pubmed: 21111053
Front Hum Neurosci. 2013 Sep 03;7:529
pubmed: 24027517
Nat Rev Neurosci. 2008 Apr;9(4):304-13
pubmed: 18319727
Neuroscientist. 2016 Feb;22(1):83-97
pubmed: 25406224
Neuron. 2018 Nov 21;100(4):977-993.e7
pubmed: 30473014
Cerebellum. 2017 Jun;16(3):695-741
pubmed: 28032321
Neuroimage. 2017 Oct 15;160:41-54
pubmed: 28034766
Neuroimage. 2012 Jan 16;59(2):1560-70
pubmed: 21907811
Neuron. 2012 May 24;74(4):753-64
pubmed: 22632732
J Neurophysiol. 2011 Nov;106(5):2322-45
pubmed: 21795627
Hum Brain Mapp. 2011 Aug;32(8):1236-49
pubmed: 20607750
Cerebellum. 2018 Apr;17(2):228-236
pubmed: 28786014
Cell Rep. 2019 May 21;27(8):2328-2334.e3
pubmed: 31116979
Front Syst Neurosci. 2010 Apr 06;4:8
pubmed: 20407579
Brain Struct Funct. 2015 Jan;220(1):37-46
pubmed: 25713839
Neurosci Lett. 2013 Feb 28;539:7-10
pubmed: 23416318
Front Neuroanat. 2012 Aug 10;6:31
pubmed: 22907994
J Neurosci. 2009 Jul 1;29(26):8586-94
pubmed: 19571149
Cereb Cortex. 2009 Oct;19(10):2485-97
pubmed: 19592571
Nat Commun. 2015 Jul 16;6:7751
pubmed: 26178017
IEEE Trans Neural Syst Rehabil Eng. 2014 May;22(3):441-52
pubmed: 24760939
Curr Biol. 2019 May 20;29(10):1689-1694.e3
pubmed: 31080082
Trends Neurosci. 2014 Dec;37(12):742-53
pubmed: 25189102