Platelet-derived growth factor C signaling is a potential therapeutic target for radiation proctopathy.
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
24 02 2021
24 02 2021
Historique:
received:
20
04
2020
accepted:
03
02
2021
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
13
7
2021
Statut:
ppublish
Résumé
Radiation proctopathy (RP) is characterized by inflammation of colorectal tissue and is a common complication of radiation therapy for pelvic malignancies with high incidence but lacking effective treatment. Here, we found that platelet-derived growth factor C (PDGF-C) and fibrosis markers were up-regulated in tissue samples from patients with RP and in rectal tissues after irradiation in a mouse model of RP. Genetic deletion of
Identifiants
pubmed: 33627485
pii: 13/582/eabc2344
doi: 10.1126/scitranslmed.abc2344
pii:
doi:
Substances chimiques
Lymphokines
0
Platelet-Derived Growth Factor
0
platelet-derived growth factor C
0
Receptors, Platelet-Derived Growth Factor
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.