Reduced anoctamin 7 (ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer.
ANO7
immunohistochemistry
prognosis
prostate cancer
Journal
Cancer biology & medicine
ISSN: 2095-3941
Titre abrégé: Cancer Biol Med
Pays: China
ID NLM: 101588850
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
25
09
2019
accepted:
07
02
2020
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Anoctamin 7 (ANO7) is a calcium ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens. ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells. ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%, moderate in 48.7%, weak in 9.3%, and negative in 7.6%. Reduced staining was tightly linked to adverse tumor features [high classical and quantitative Gleason grade, lymph node metastasis, advanced tumor stage, high Ki67 labeling index, positive surgical margin, and early biochemical recurrence ( These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa. ANO7 measurement, either alone or in combination, might provide clinically useful prognostic information in PCa.
Identifiants
pubmed: 33628598
doi: 10.20892/j.issn.2095-3941.2019.0324
pii: j.issn.2095-3941.2019.0324
pmc: PMC7877177
doi:
Substances chimiques
ANO7 protein, human
0
Anoctamins
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
245-255Informations de copyright
Copyright: © 2021, Cancer Biology & Medicine.
Déclaration de conflit d'intérêts
Conflict of interest statement No potential conflicts of interest are disclosed.
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