Anti-Inflammatory Effects of Melatonin and 5-Methoxytryptophol on Lipopolysaccharide-Induced Acute Pulpitis in Rats.
Acute Disease
Animals
Anti-Inflammatory Agents
/ pharmacology
Female
Indoles
/ pharmacology
Interleukin-1beta
/ blood
Lipopolysaccharides
/ toxicity
Male
Matrix Metalloproteinase 1
/ blood
Matrix Metalloproteinase 2
/ blood
Melatonin
/ pharmacology
Pulpitis
/ blood
Rats
Rats, Wistar
Tumor Necrosis Factor-alpha
/ blood
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
18
09
2020
revised:
26
12
2020
accepted:
06
02
2021
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
26
5
2021
Statut:
epublish
Résumé
The aim of this study was to investigate the possible therapeutic impacts of two pineal hormones, melatonin and 5-methoxytryptophol (5-MTX), in a rat model of acute pulpitis by analyzing biochemical and histopathological parameters. This research was done using 32 male and female Wistar albino rats with weight between 200 and 250 g. The rats were randomly divided into four groups: a control group (rats without any treatment), acute pulpitis (AP) group, AP+melatonin group, and AP+5-MTX group. In the AP-induced groups, the crowns of the upper left incisors were removed horizontally. Lipopolysaccharide solution was applied to the exposed pulp tissue before the canal orifices were sealed with a temporary filling material. Melatonin (10 mg/kg) and 5-MTX (5 mg/kg) were administered intraperitoneally. The rats were sacrificed 24 hours after pulp injury, and trunk blood and pulp samples were collected. The concentrations of TNF- TNF- Both melatonin and 5-MTX provided protective effects on acute pulpitis, which indicates they may be promising as a therapeutic strategy for oral disease.
Identifiants
pubmed: 33628825
doi: 10.1155/2021/8884041
pmc: PMC7895566
doi:
Substances chimiques
Anti-Inflammatory Agents
0
IL1B protein, rat
0
Indoles
0
Interleukin-1beta
0
Lipopolysaccharides
0
Tumor Necrosis Factor-alpha
0
methoxytryptophol
712-09-4
Matrix Metalloproteinase 2
EC 3.4.24.24
Mmp2 protein, rat
EC 3.4.24.24
MMP1 protein, rat
EC 3.4.24.7
Matrix Metalloproteinase 1
EC 3.4.24.7
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8884041Informations de copyright
Copyright © 2021 Fatma Kermeoğlu et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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