Ascertaining and classifying cases of congenital anomalies in the ALSPAC birth cohort.
ALSPAC
birth cohort
congenital anomaly
congenital heart disease
longitudinal cohort
record linkage
Journal
Wellcome open research
ISSN: 2398-502X
Titre abrégé: Wellcome Open Res
Pays: England
ID NLM: 101696457
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
30
09
2020
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
26
2
2021
Statut:
epublish
Résumé
Congenital anomalies (CAs) are structural or functional disorders that occur during intrauterine life. Longitudinal cohort studies provide unique opportunities to investigate potential causes and consequences of these disorders. In this data note, we describe how we identified cases of major CAs, with a specific focus on congenital heart diseases (CHDs), in the Avon Longitudinal Study of Parents and Children (ALSPAC). We demonstrate that combining multiple sources of data including data from antenatal, delivery, primary and secondary health records, and parent-reported information can improve case ascertainment. Our approach identified 590 participants with a CA according to the Euro Registers of Congenital Anomalies (EUROCAT) guidelines, 127 of whom had a CHD. We describe the methods that identified these cases and provide statistics on subtypes of anomalies. The data note contains details on the processes required for researchers to access these data.
Identifiants
pubmed: 33628950
doi: 10.12688/wellcomeopenres.16339.1
pmc: PMC7871361
doi:
Types de publication
Journal Article
Langues
eng
Pagination
231Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Informations de copyright
Copyright: © 2020 Taylor K et al.
Déclaration de conflit d'intérêts
Competing interests: D.A.L reports support from Roche Diagnostics and Medtronic Ltd for research unrelated to that presented here. All other authors declare no conflicts of interest.
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