Early development of human ganglionic eminences assessed
brain
fetal development
ganglionic eminences
micro-MRI
Journal
Medicine and pharmacy reports
ISSN: 2668-0572
Titre abrégé: Med Pharm Rep
Pays: Romania
ID NLM: 101742144
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
10
05
2020
revised:
21
06
2020
accepted:
07
07
2020
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
26
2
2021
Statut:
ppublish
Résumé
Ganglionic eminences are temporary structures which appear during the 5 Six human embryos and fetuses ranging from 21 mm crown-rump length CRL (9 gestational week GW) to 85 mm CRL (14 GW) were examined in vitro by micro-MRI. The investigation was performed with a Bruker BioSpec 70/16USR scanner (Bruker BioSpin MRI GmbH, Ettlingen, Germany) operating at 7.04 Tesla. We describe the morphological characteristics of the ganglionic eminences at different gestational ages. The acquisition parameters were modified for each subject in order to obtain an increased spatial resolution. The remarkable spatial resolution of 27 μm/voxel allows visualization of millimetric structures of the developing brain on high quality micro-MR images. In our study we give the description of the ganglionic eminences within the embryonic and early fetal brains by using micro-MRI, which, to the best of our knowledge, have not been previously documented in literature. Micro-MRI provides accurate images, which are comparable with the histological slices.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Ganglionic eminences are temporary structures which appear during the 5
METHODS
METHODS
Six human embryos and fetuses ranging from 21 mm crown-rump length CRL (9 gestational week GW) to 85 mm CRL (14 GW) were examined in vitro by micro-MRI. The investigation was performed with a Bruker BioSpec 70/16USR scanner (Bruker BioSpin MRI GmbH, Ettlingen, Germany) operating at 7.04 Tesla.
RESULTS
RESULTS
We describe the morphological characteristics of the ganglionic eminences at different gestational ages. The acquisition parameters were modified for each subject in order to obtain an increased spatial resolution. The remarkable spatial resolution of 27 μm/voxel allows visualization of millimetric structures of the developing brain on high quality micro-MR images.
CONCLUSION
CONCLUSIONS
In our study we give the description of the ganglionic eminences within the embryonic and early fetal brains by using micro-MRI, which, to the best of our knowledge, have not been previously documented in literature. Micro-MRI provides accurate images, which are comparable with the histological slices.
Identifiants
pubmed: 33629046
doi: 10.15386/mpr-1715
pii: cm-94-35
pmc: PMC7880059
doi:
Types de publication
Journal Article
Langues
eng
Pagination
35-42Références
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