IL-6 can singlehandedly drive many features of frailty in mice.

Aging / pathology Animals Cytokines Frailty Interleukin-6 Mice
Frailty IL-6 Mouse Transgenic models

Journal

GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284

Informations de publication

Date de publication:
04 2021
Historique:
received: 09 02 2021
accepted: 14 02 2021
pubmed: 26 2 2021
medline: 1 6 2021
entrez: 25 2 2021
Statut: ppublish

Résumé

Frailty is a geriatric syndrome characterized by age-related declines in function and reserve resulting in increased vulnerability to stressors. The most consistent laboratory finding in frail subjects is elevation of serum IL-6, but it is unclear whether IL-6 is a causal driver of frailty. Here, we characterize a new mouse model of inducible IL-6 expression (IL-6

Identifiants

DOI: 10.1007/s11357-021-00343-z PMID: 33629207 PMC: PMC8110675
pubmed: 33629207
doi: 10.1007/s11357-021-00343-z
pii: 10.1007/s11357-021-00343-z
pmc: PMC8110675
doi:

Substances chimiques

Cytokines 0
Interleukin-6 0
interleukin-6, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

539-549

Subventions

Organisme : NIEHS NIH HHS
ID : T32 ES007091
Pays : United States

Références

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Auteurs

Mladen Jergović (M)

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.
ORCID: 0000-0002-7630-1219

Heather L Thompson (HL)

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.
Ventana-Roche Medical Systems, Oro Valley, AZ, USA.

Christine M Bradshaw (CM)

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.

Sandip Ashok Sonar (SA)

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.

Arveen Ashgar (A)

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.

Niels Mohty (N)

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.

Bellal Joseph (B)

Division of Trauma Surgery, Department of Surgery, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.

Mindy J Fain (MJ)

University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA.
Division of Geriatrics, General Internal Medicine and Palliative Medicine, Department of Medicine, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.

Kristan Cleveland (K)

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA.

Rick G Schnellman (RG)

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA.
Southern Arizona Veterans Affairs Health Care System, Tucson, AZ, USA.
Southwest Environmental Health Science Center, University of Arizona, Tucson, AZ, USA.

Janko Nikolich-Žugich (J)

Department of Immunobiology, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA. mjergovic@arizona.edu.
University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, P.O.Box. 249221, 1501 N. Campbell Ave., Tucson, AZ, 85724, USA. mjergovic@arizona.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › IL-6 can singlehandedly drive many features of...
questionsmedicales.fr › Eucaryotes › Animaux › IL-6 can singlehandedly drive many features of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › IL-6 can singlehandedly drive many features of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fragilité › IL-6 can singlehandedly drive many features of...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › IL-6 can singlehandedly drive many features of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › IL-6 can singlehandedly drive many features of...