Immunohistochemical characteristics of lateral bone augmentation using different biomaterials around chronic peri-implant dehiscence defects: An experimental in vivo study.
animal experiments
biomaterials
bone substitutes
guided bone regeneration
Journal
Clinical oral implants research
ISSN: 1600-0501
Titre abrégé: Clin Oral Implants Res
Pays: Denmark
ID NLM: 9105713
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
04
01
2021
received:
18
05
2020
accepted:
17
02
2021
pubmed:
26
2
2021
medline:
15
5
2021
entrez:
25
2
2021
Statut:
ppublish
Résumé
To investigate the immunohistochemical characteristics of a highly porous synthetic bone substitute and a cross-linked collagen membrane for guided bone regeneration. Three experimental groups were randomly allocated at chronic peri-implant dehiscence defect in 8 beagle dogs: (i) biphasic calcium phosphate covered by a cross-linked collagen membrane (test group), (ii) deproteinized bovine bone mineral covered by a natural collagen membrane (positive control) and (iii) no treatment (negative control). After 8 and 16 weeks of submerged healing, dissected tissue blocks were processed for immunohistochemical analysis. Seven antibodies were used to detect the remaining osteogenic and angiogenic potential, and quantitative immunohistochemical analysis was done by software. The antigen reactivity of alkaline phosphatase was significantly higher in the test group compared to the positive and negative controls, and it maintained till 16 weeks. The intensity of osteocalcin was significantly higher in the positive control at 8 weeks than the other groups, but significantly decreased at 16 weeks and no difference was found between the groups. A significant large number of TRAP-positive cells were observed in the test group mainly around the remaining particles at 16 weeks. The angiogenic potential was comparable between the groups showing no difference in the expression of transglutaminase II and vascular endothelial growth factor. Guided bone regeneration combining a highly porous biphasic calcium phosphate synthetic biomaterial with a crosslinked collagen membrane, resulted in extended osteogenic potential when compared to the combination of deproteinized bovine bone mineral and a native collagen membrane.
Substances chimiques
Biocompatible Materials
0
Bone Substitutes
0
Dental Implants
0
Membranes, Artificial
0
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Langues
eng
Pagination
569-580Subventions
Organisme : Dentium
Organisme : Osteology Foundation
ID : 16-004
Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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