Xanthohumol Microbiome and Signature in Healthy Adults (the XMaS Trial): Safety and Tolerability Results of a Phase I Triple-Masked, Placebo-Controlled Clinical Trial.
clinical trial
phase I
safety
tolerability
xanthohumol
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
21
01
2021
received:
09
12
2020
pubmed:
26
2
2021
medline:
20
11
2021
entrez:
25
2
2021
Statut:
ppublish
Résumé
Xanthohumol, a prenylflavonoid from hops, has been extensively studied preclinically but has undergone limited research in human subjects. A triple-masked, placebo-controlled phase I clinical trial was conducted to examine the safety and tolerability of xanthohumol. Thirty healthy volunteers were randomized to 24 mg day Over an eight-week period, 24 mg daily xanthohumol was safe and well-tolerated by healthy adults.
Identifiants
pubmed: 33629812
doi: 10.1002/mnfr.202001170
pmc: PMC8221389
mid: NIHMS1707595
doi:
Substances chimiques
Biomarkers
0
Flavonoids
0
Placebos
0
Propiophenones
0
xanthohumol
T4467YT1NT
Types de publication
Clinical Trial, Phase I
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2001170Subventions
Organisme : NCCIH NIH HHS
ID : K24 AT011568
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT010271
Pays : United States
Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
Glob Adv Health Med. 2019 Jul 29;8:2164956119867251
pubmed: 31384513
Mol Nutr Food Res. 2014 Oct;58(10):1962-9
pubmed: 25045111
Nutrients. 2018 Jan 04;10(1):
pubmed: 29300341
ACR Open Rheumatol. 2020 Jun;2(6):320-329
pubmed: 32386128
Clin Ther. 2018 May;40(5):672-673
pubmed: 29703431
Mol Nutr Food Res. 2016 Apr;60(4):773-86
pubmed: 26840505
J Agric Food Chem. 2000 Sep;48(9):3876-84
pubmed: 10995285
Mol Nutr Food Res. 2005 Sep;49(9):821-3
pubmed: 16144029
Mol Nutr Food Res. 2018 Mar;62(6):e1700692
pubmed: 29322620
Arthritis Care Res (Hoboken). 2017 Sep;69(9):1312-1321
pubmed: 28029753
J Chromatogr A. 1999 Feb 5;832(1-2):97-107
pubmed: 10070768
Mol Nutr Food Res. 2014 Feb;58(2):248-55
pubmed: 24038952
Sci Rep. 2018 Jan 12;8(1):613
pubmed: 29330372
J Clin Epidemiol. 2016 May;73:89-102
pubmed: 26952842
Qual Life Res. 2018 Jul;27(7):1885-1891
pubmed: 29569016
N Engl J Med. 2011 Jul 7;365(1):3-5
pubmed: 21651388
J Agric Food Chem. 2005 Aug 10;53(16):6281-8
pubmed: 16076107
Trials. 2020 Oct 7;21(1):835
pubmed: 33028396
Drug Test Anal. 2016 Mar-Apr;8(3-4):271-82
pubmed: 26593452
Mol Nutr Food Res. 2020 Jan;64(1):e1900789
pubmed: 31755244
Phytochem Rev. 2016 Jun;15(3):425-444
pubmed: 27274718
Food Chem Toxicol. 2018 Aug;118:963-971
pubmed: 29626579
J Nutr. 2006 Jul;136(7):1862-7
pubmed: 16772450