Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes.
Action Potentials
Adult
Aged
Animals
Atrial Fibrillation
/ enzymology
Atrial Remodeling
Case-Control Studies
Cell Line
Disease Models, Animal
Epigenesis, Genetic
Female
Heart Atria
/ enzymology
Heart Rate
Histone Deacetylase 2
/ genetics
Humans
Male
Middle Aged
Myocytes, Cardiac
/ enzymology
Potassium Channels
/ genetics
Repressor Proteins
/ genetics
Sus scrofa
Time Factors
Atrial fibrillation
Electrophysiology
Epigenetics
Histone deacetylase
K+ channel
Journal
Basic research in cardiology
ISSN: 1435-1803
Titre abrégé: Basic Res Cardiol
Pays: Germany
ID NLM: 0360342
Informations de publication
Date de publication:
25 02 2021
25 02 2021
Historique:
received:
23
11
2020
accepted:
18
02
2021
entrez:
25
2
2021
pubmed:
26
2
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key role for epigenetic mechanisms in the regulation of ion channel expression. Histone deacetylases (HDACs) control gene expression through deacetylation of histone proteins. We hypothesized that class I HDACs in complex with neuron-restrictive silencer factor (NRSF) determine atrial K
Identifiants
pubmed: 33630168
doi: 10.1007/s00395-021-00855-x
pii: 10.1007/s00395-021-00855-x
doi:
Substances chimiques
Potassium Channels
0
RE1-silencing transcription factor
0
Repressor Proteins
0
HDAC2 protein, human
EC 3.5.1.98
Histone Deacetylase 2
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13Subventions
Organisme : University of Heidelberg, Faculty of Medicine
ID : Postdoctoral Fellowships
Organisme : University of Heidelberg, Faculty of Medicine
ID : Postdoctoral Fellowship
Organisme : Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
ID : Fellowship
Organisme : Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
ID : Fellowship
Organisme : Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
ID : Otto-Hess-Promotionsstipendium
Organisme : Deutsche Stiftung für Herzforschung
ID : F/08/14
Organisme : Deutsche Stiftung für Herzforschung
ID : Fellowship
Organisme : Deutsche Stiftung für Herzforschung
ID : Kaltenbach-Promotionsstipendium
Organisme : Deutsche Stiftung für Herzforschung
ID : Kaltenbach-Promotionsstipendium
Organisme : Deutsche Stiftung für Herzforschung
ID : Kaltenbach-Promotionsstipendium
Organisme : German Internal Medicine Society
ID : Clinician-Scientist-Program
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHW 1611/-1
Organisme : Deutsche Forschungsgemeinschaft
ID : TH 1120/7-1
Organisme : Deutsche Forschungsgemeinschaft
ID : TH 1120/8-1
Organisme : Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
ID : Sonderlinie Medizin
Organisme : Heidelberg Research Center for Molecular Medicine
ID : Senior Career Fellowship
Organisme : Department of Cardiology, University of Heidelberg
ID : Cardiology Career Program
Organisme : Department of Cardiology, University of Heidelberg
ID : Cardiology Career Program
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