A new quantitative index in the diagnosis of Parkinson syndrome by dopamine transporter single-photon emission computed tomography.
Adult
Aged
Aged, 80 and over
Biological Transport
Diagnosis, Differential
Dopamine Plasma Membrane Transport Proteins
/ metabolism
Female
Humans
Iodine Radioisotopes
/ chemistry
Male
Middle Aged
Nortropanes
/ chemistry
Parkinson Disease
/ classification
Phantoms, Imaging
ROC Curve
Retrospective Studies
Tomography, Emission-Computed, Single-Photon
/ methods
Active dopamine transporter volume
Dopamine transporter SPECT
Functional dopamine transporter volume
Parkinson syndrome
SUV
Journal
Annals of nuclear medicine
ISSN: 1864-6433
Titre abrégé: Ann Nucl Med
Pays: Japan
ID NLM: 8913398
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
26
07
2020
accepted:
28
01
2021
pubmed:
26
2
2021
medline:
26
10
2021
entrez:
25
2
2021
Statut:
ppublish
Résumé
Dopamine transporter single-photon emission computed tomography (DAT SPECT) has been widely used to diagnose Parkinson syndrome. Using the standardized uptake value (SUV) of DAT SPECT, we propose "functional dopamine transporter volume (f-DTV)" as a new quantitative index to evaluate the three-dimensional volume of functional dopamine transporters and assess its diagnostic ability in differentiating dopaminergic neurodegenerative diseases (dNDD) from non-dNDD. Seventy-nine patients were enrolled (42 dNDD, 37 non-dNDD; 38 men; age 24-88 years). We analyzed seven quantitative indices. The specific binding ratio (SBR) was calculated using a program specialized for DAT SPECT (SBR_Bolt). The SUVmax, SUVpeak, and SUVmean were calculated using a quantification program for bone SPECT. SBR_SUV was calculated by dividing striatal SUVmean by the average of background SUVmean. The cutoff value of the active dopamine transporter level was examined using three methods (threshold of 40% of SUVmax, SUV 2, and SUV 3) to calculate the active dopamine transporter volume (ADV). The f-DTV was calculated by multiplying ADV and SUV The SBR_Bolt and SBR_SUV highly correlated with each other (r = 0.71). The cutoff value of the active dopamine transporter level was determined as SUV 3. All seven quantitative indices showed lower values in the dNDD group than in the non-dNDD group, and the difference between the two groups was statistically significant (p < 0.05). Sensitivity, specificity, and AUC of f-DTV were slightly lower than those of SBR_Bolt (71%, 79%, and 0.81, respectively, for f-DTV, and 81%, 84%, 0.88, respectively, for SBR_Bolt). The difference in AUC between f-DTV and SBR_Bolt was not statistically significant. This study demonstrates the utility of f-DTV as a novel quantitative index for evaluating the three-dimensional volume of functional dopamine transporters, and that f-DTV has almost the same diagnostic ability to differentiate dNDD from non-dNDD using DAT SPECT.
Identifiants
pubmed: 33630226
doi: 10.1007/s12149-021-01592-w
pii: 10.1007/s12149-021-01592-w
doi:
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Iodine Radioisotopes
0
Nortropanes
0
Iodine-123
8YWR746RPQ
ioflupane
VF232WE742
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
504-513Références
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