Effect of Occipital Nerve Stimulation (ONS) on the Orbicularis Oculi Reflex Triggered by a Standardized Air Flow in Patients with Chronic Migraine-A Prospective, Randomized, Interventional Study.
Blink reflex
Central sensitization
Chronic migraine
Dynamic stimulation
Mode of action
ONS
Occipital nerve stimulation
Orbicularis oculi reflex
Peripheral sensitization
Standardized air flow
Journal
Pain and therapy
ISSN: 2193-8237
Titre abrégé: Pain Ther
Pays: New Zealand
ID NLM: 101634491
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
08
01
2021
accepted:
04
02
2021
pubmed:
26
2
2021
medline:
26
2
2021
entrez:
25
2
2021
Statut:
ppublish
Résumé
Occipital nerve stimulation (ONS) is a specific form of peripheral neuromodulation used in the treatment of chronic pain disorders. A particular field of application is in the therapy of treatment-refractory headaches, especially of chronic migraine. The precise mode of action is unknown. It is presumed that central and peripheral sensitization are reduced in patients with chronic headache. The aim of this study was to examine the effect of ONS on pain-modulatory mechanisms in the trigeminocervical area in patients with chronic migraine. In a balanced repeated measurements design in eight patients with chronic migraine with and without active ONS, we analyzed which effects ONS had on the orbicularis oculi reflex dynamically elicited by corneal air flow. The orbicularis oculi reflex in active ONS (7.38 ± 20.14 eyelid closures/minute) compared to inactive ONS (18.73 ± 14.30 eyelid closures/minute) is significantly reduced (p = 0.021). The results show that under active ONS compared to inactive ONS in patients with chronic migraine, the orbicularis oculi reflex, dynamically triggered by a standardized air flow, is significantly reduced. This suggests that ONS is able to directly counteract the trigeminally mediated central sensitization in chronic migraine and protectively reduce the effects of aversive peripheral stimulation.
Identifiants
pubmed: 33630252
doi: 10.1007/s40122-021-00242-3
pii: 10.1007/s40122-021-00242-3
pmc: PMC8119542
doi:
Types de publication
Journal Article
Langues
eng
Pagination
567-576Références
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