Can vitamin E supplementation affect obesity indices? A systematic review and meta-analysis of twenty-four randomized controlled trials.

Body Mass Index Body Weight / drug effects Dietary Supplements Humans Obesity / drug therapy Vitamin E / pharmacology Vitamins / pharmacology Waist Circumference / drug effects
Meta-analysis Obesity Systematic review Tocopherol Vitamin E Weight

Journal

Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603

Informations de publication

Date de publication:
05 2021
Historique:
received: 04 05 2020
revised: 29 01 2021
accepted: 01 02 2021
pubmed: 27 2 2021
medline: 2 9 2021
entrez: 26 2 2021
Statut: ppublish

Résumé

Several mechanisms have been proposed for the effect of vitamin E on weight loss. Yet various interventional studies with wide ranges of doses and durations have reported contradictory results. Cochrane Library, PubMed, Scopus, and Embase databases were searched up to December 2020. Meta-analysis was performed using random-effect method. Effect size was presented as weighted mean difference (WMD) and 95% confidence interval (CI). Heterogeneity was evaluated using the I A total of 24 studies with 33 data sets were included. There was no significant effect of vitamin E on weight (WMD: 0.15, 95% CI: -1.35 to 1.65, P = 0.847), body mass index (BMI) (WMD = 0.04, 95% CI: -0.29 to 0.37, P = 0.815), and waist circumference (WC) (WMD = -0.19 kg, 95% CI: -2.06 to 1.68, P = 0.842), respectively. However, subgroup analysis revealed that vitamin E supplementation in studies conducted on participants with normal BMI (18.5-24.9) had increasing impact on BMI (P = 0.047). There was no significant effect of vitamin E supplementation on weight, BMI and WC. However, vitamin E supplementation might be associated with increasing BMI in people with normal BMI (18.5-24.9).

Sections du résumé

BACKGROUND
Several mechanisms have been proposed for the effect of vitamin E on weight loss. Yet various interventional studies with wide ranges of doses and durations have reported contradictory results.
METHODS
Cochrane Library, PubMed, Scopus, and Embase databases were searched up to December 2020. Meta-analysis was performed using random-effect method. Effect size was presented as weighted mean difference (WMD) and 95% confidence interval (CI). Heterogeneity was evaluated using the I
RESULTS
A total of 24 studies with 33 data sets were included. There was no significant effect of vitamin E on weight (WMD: 0.15, 95% CI: -1.35 to 1.65, P = 0.847), body mass index (BMI) (WMD = 0.04, 95% CI: -0.29 to 0.37, P = 0.815), and waist circumference (WC) (WMD = -0.19 kg, 95% CI: -2.06 to 1.68, P = 0.842), respectively. However, subgroup analysis revealed that vitamin E supplementation in studies conducted on participants with normal BMI (18.5-24.9) had increasing impact on BMI (P = 0.047).
CONCLUSION
There was no significant effect of vitamin E supplementation on weight, BMI and WC. However, vitamin E supplementation might be associated with increasing BMI in people with normal BMI (18.5-24.9).

Identifiants

DOI: 10.1016/j.clnu.2021.02.002 PMID: 33632535
pubmed: 33632535
pii: S0261-5614(21)00076-5
doi: 10.1016/j.clnu.2021.02.002
pii:
doi:

Substances chimiques

Vitamins 0
Vitamin E 1406-18-4

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3201-3209

Informations de copyright

Copyright © 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest All authors declared no conflicts of interest.

Auteurs

Mohammad Reza Emami (MR)

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Sanaz Jamshidi (S)

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Meysam Zarezadeh (M)

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: zarezadehm@tbzmed.ac.ir.

Masoud Khorshidi (M)

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: khorshidi.m@iums.ac.ir.

Beheshteh Olang (B)

Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Zohreh Sajadi Hezaveh (Z)

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mohammadhassan Sohouli (M)

Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.

Naheed Aryaeian (N)

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Electronic address: aryaeian.n@iums.ac.ir.

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Classifications MeSH

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