In-field stereotactic body radiotherapy (SBRT) reirradiation for pulmonary malignancies as a multicentre analysis of the German Society of Radiation Oncology (DEGRO).


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
25 02 2021
Historique:
received: 20 12 2020
accepted: 29 01 2021
entrez: 26 2 2021
pubmed: 27 2 2021
medline: 21 12 2021
Statut: epublish

Résumé

Data of thoracic in-field reirradiation with two courses of stereotactic body radiotherapy (SBRT) is scarce. Aim of this study is to investigate feasibility and safety of this approach. Patients with a second course of thoracic SBRT and planning target volume (PTV) overlap were analyzed in this retrospective, multicenter study. All plans and clinical data were centrally collected. 27 patients from 8 centers have been amenable for evaluation: 12 with non-small-cell lung cancer, 16 with metastases, treated from 2009 (oldest first course) to 2020 (latest second course). A median dose of 38.5 Gy to the 65%-isodose over a median of 5 fractions was prescribed in the first course and 40 Gy in 5 fractions for the second SBRT-course. Median PTV of the second SBRT was 29.5 cm

Identifiants

pubmed: 33633130
doi: 10.1038/s41598-021-83210-3
pii: 10.1038/s41598-021-83210-3
pmc: PMC7907095
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

4590

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Auteurs

Caroline John (C)

Department of Radiation Oncology, University Hospital Zürich, University of Zurich, Zurich, Switzerland.

Riccardo Dal Bello (R)

Department of Radiation Oncology, University Hospital Zürich, University of Zurich, Zurich, Switzerland.

Nicolaus Andratschke (N)

Department of Radiation Oncology, University Hospital Zürich, University of Zurich, Zurich, Switzerland.

Matthias Guckenberger (M)

Department of Radiation Oncology, University Hospital Zürich, University of Zurich, Zurich, Switzerland.

Judit Boda-Heggemann (J)

Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Eleni Gkika (E)

Department of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany.

Frederick Mantel (F)

Department of Radiation Oncology, University Hospital Würzburg, Würzburg, Germany.

Hanno M Specht (HM)

Clinic for Radiation Oncology Freising, Freising, Germany.

Carmen Stromberger (C)

Department of Radiation Oncology, Charite - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Franz Zehentmayr (F)

Department of Radiation Oncology, Paracelsus Medical University, Salzburg, Austria.

Oliver Blanck (O)

Department of Radiation Oncology, University Medical Center Schleswig-Holstein, Kiel, Germany.

Panagiotis Balermpas (P)

Department of Radiation Oncology, University Hospital Zürich, University of Zurich, Zurich, Switzerland. Panagiotis.balermpas@usz.ch.
Department of Radiation Oncology, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. Panagiotis.balermpas@usz.ch.

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Classifications MeSH