Emerging Role of Long Non-Coding RNAs in the Pathobiology of Glioblastoma.
circRNA
expression
glioblastoma
lncRNA
polymorphism
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
04
11
2020
accepted:
22
12
2020
entrez:
26
2
2021
pubmed:
27
2
2021
medline:
27
2
2021
Statut:
epublish
Résumé
Glioblastoma is the utmost aggressive diffuse kind of glioma which is originated from astrocytes, neural stem cells or progenitors. This malignant tumor has a poor survival rate. A number of genetic aberrations and somatic mutations have been associated with this kind of cancer. In recent times, the impact of long non-coding RNAs (lncRNAs) in glioblastoma has been underscored by several investigations. Up-regulation of a number of oncogenic lncRNAs such as H19, MALAT1, SNHGs, MIAT, UCA, HIF1A-AS2 and XIST in addition to down-regulation of other tumor suppressor lncRNAs namely GAS5, RNCR3 and NBAT1 indicate the role of these lncRNAs in the pathogenesis of glioblastoma. Several
Identifiants
pubmed: 33634032
doi: 10.3389/fonc.2020.625884
pmc: PMC7901982
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
625884Informations de copyright
Copyright © 2021 Rezaei, Tamizkar, Sharifi, Taheri and Ghafouri-Fard.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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