Analysis of opacification patterns in intraocular lenses (IOL).
lens and zonules
optics and refraction
Journal
BMJ open ophthalmology
ISSN: 2397-3269
Titre abrégé: BMJ Open Ophthalmol
Pays: England
ID NLM: 101714806
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
08
2020
revised:
10
11
2020
accepted:
01
12
2020
entrez:
26
2
2021
pubmed:
27
2
2021
medline:
27
2
2021
Statut:
epublish
Résumé
Intraocular lens (IOL) opacification may cause severe visual impairment. The pathogenesis remains unclear. The aim of this study was to analyse opacification patterns in different IOLs. Therefore, this multicentre, retrospective, observational study was conducted at Ludwig-Maximilians-University, Munich, Germany and University-Hospital Basel, Switzerland. In this study, 75 opacified IOLs were identified and classified after extraction. Macroscopical photo documentation, light and electron microscopic analysis were done. 68 acrylic-hydrophilic single-piece-IOLs, 1 acrylic-hydrophilic 3-piece-IOL, 6 acrylic-hydrophobic 3-piece-IOLs were extracted. The dataset comprised IOLs known for opacification and IOLs not having been reported yet. 67 IOLs showed a fine-granular and 8 IOLs a crust-like opacification pattern. According to literature, 62 of the fine-granular opacified IOLs were graded into type 1 (processing/packaging-induced primary opacification) and 13 into type 2 (secondary opacification of unknown aetiology). The anterior surface of the IOLs was affected in all 75 IOLs, the posterior surface only in 23 cases. Of all 67 fine-granular IOLs, 43 had a central defect and 21 had a zone without opacification (clear islet). In our series, the morphology of IOL opacification did not follow the existing pathogenetic classification that strictly discriminates between primary and secondary causes. Fine-granular IOL opacification occurs with similar patterns in both type 1 and type 2 IOL opacification, while a crust-like pattern was only detected in type 2 IOL opacifications. Consequently, susceptibility of an IOL to opacification is caused by a multifactorial combination of material and processing properties as well as individual (pathological) conditions of the patient.
Identifiants
pubmed: 33634210
doi: 10.1136/bmjophth-2020-000589
pii: bmjophth-2020-000589
pmc: PMC7880112
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e000589Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Br J Ophthalmol. 2006 Mar;90(3):285-8
pubmed: 16488945
Ophthalmology. 2010 Aug;117(8):1486-92
pubmed: 20537395
Am J Ophthalmol. 2004 Jun;137(6):979-87
pubmed: 15183780
Taiwan J Ophthalmol. 2019 Jan-Mar;9(1):49-52
pubmed: 30993069
J Cataract Refract Surg. 2001 Sep;27(9):1485-92
pubmed: 11566535
Materials (Basel). 2020 Sep 17;13(18):
pubmed: 32957729
Ophthalmologe. 2019 Sep;116(9):882-886
pubmed: 30506097
J Cataract Refract Surg. 2019 Sep;45(9):1330-1334
pubmed: 31371148
Eur J Ophthalmol. 2020 Sep;30(5):823-839
pubmed: 31387387
J Cataract Refract Surg. 2020 Jan;46(1):20-26
pubmed: 32050228
Graefes Arch Clin Exp Ophthalmol. 1991;229(4):371-9
pubmed: 1916326
Cornea. 2015 Nov;34(11):1375-7
pubmed: 26312617
Ophthalmology. 2020 Jun 30;:
pubmed: 32619547
Graefes Arch Clin Exp Ophthalmol. 2019 Jan;257(1):125-134
pubmed: 30413876
Korean J Ophthalmol. 2007 Jun;21(2):90-4
pubmed: 17592239
BMC Public Health. 2013 Feb 23;13:166
pubmed: 23433228
J Cataract Refract Surg. 2019 Dec;45(12):1801-1807
pubmed: 31856993
Clin Exp Ophthalmol. 2020 Jan;48(1):89-97
pubmed: 31581356
Ophthalmology. 2008 Jan;115(1):73-9
pubmed: 17498804
J Cataract Refract Surg. 2006 Nov;32(11):1932-7
pubmed: 17081899
J Cataract Refract Surg. 2007 Apr;33(4):713-26
pubmed: 17397749
Am J Ophthalmol. 2018 Sep;193:10-19
pubmed: 29890164
Am J Ophthalmol. 2008 Sep;146(3):395-403
pubmed: 18602078
J Cataract Refract Surg. 2018 May;44(5):615-622
pubmed: 29891155
Exp Eye Res. 1965 Sep;4(3):179-86
pubmed: 5839235
J Cataract Refract Surg. 2015 Jun;41(6):1310-4
pubmed: 26100959
Clin Exp Optom. 2002 Nov;85(6):335-49
pubmed: 12452784
Ophthalmology. 2020 Jul 8;:
pubmed: 32652203
Dtsch Arztebl Int. 2016 Mar 18;113(11):177-82
pubmed: 27118665
J Cataract Refract Surg. 2008 Sep;34(9):1584-91
pubmed: 18721724
Cornea. 2016 Sep;35(9):e28-30
pubmed: 27429090
Br J Ophthalmol. 2019 Dec;103(12):1700-1703
pubmed: 30798263
Int Ophthalmol. 2017 Dec;37(6):1337-1339
pubmed: 27942981
Acta Ophthalmol (Copenh). 1966;44(1):64-8
pubmed: 5952960
BMJ Open Ophthalmol. 2018 Dec 15;3(1):e000157
pubmed: 30623024
Open Ophthalmol J. 2010 Sep 03;4:52-9
pubmed: 21293732