Prevalence and trend of allergen sensitization in patients with nummular (discoid) eczema referred for patch testing: North American Contact Dermatitis Group data, 2001-2016.
allergic contact
coin-shaped
dermatitis
discoid
epidemiology
health
itch
nummular eczema
patch test
pruritus
rash
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
09
02
2021
received:
18
01
2021
accepted:
10
02
2021
pubmed:
27
2
2021
medline:
26
11
2021
entrez:
26
2
2021
Statut:
ppublish
Résumé
Few studies have examined the relationship between nummular (discoid) eczema (NE) and allergic contact dermatitis (ACD). To examine trends, associations, and clinical relevance of ACD in patients with NE who were referred for patch testing. Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group. Overall, 748 patients (1.9%) were diagnosed with NE; 23.9% had a concomitant diagnosis of ACD. The prevalence of NE fluctuated over time between 2001 and 2016, with no overall change in prevalence in diagnosed NE. In multivariable logistic regression models, NE increased steadily with age and was associated with male sex and Asian and other race/ethnicity, and inversely associated with a history of atopic dermatitis (AD) and hay fever. Patients with NE had lower proportions of one or more positive allergic reactions and lower odds of a positive reaction in multiple individual allergens. The most commonly relevant allergens in patients with NE were formaldehyde 2.0% aq., methylisothiazolinone, quaternium 15, fragrance mix I, and propylene glycol. NE is a heterogeneous disorder with distinct subsets of lesional distributions and a profile of relevant allergens, especially formaldehyde and formaldehyde releasers. Nearly one in four patients with NE had ACD, supporting the role of patch testing in patients with NE.
Sections du résumé
BACKGROUND
BACKGROUND
Few studies have examined the relationship between nummular (discoid) eczema (NE) and allergic contact dermatitis (ACD).
OBJECTIVE
OBJECTIVE
To examine trends, associations, and clinical relevance of ACD in patients with NE who were referred for patch testing.
METHODS
METHODS
Retrospective analysis of 38 723 patients from the North American Contact Dermatitis Group.
RESULTS
RESULTS
Overall, 748 patients (1.9%) were diagnosed with NE; 23.9% had a concomitant diagnosis of ACD. The prevalence of NE fluctuated over time between 2001 and 2016, with no overall change in prevalence in diagnosed NE. In multivariable logistic regression models, NE increased steadily with age and was associated with male sex and Asian and other race/ethnicity, and inversely associated with a history of atopic dermatitis (AD) and hay fever. Patients with NE had lower proportions of one or more positive allergic reactions and lower odds of a positive reaction in multiple individual allergens. The most commonly relevant allergens in patients with NE were formaldehyde 2.0% aq., methylisothiazolinone, quaternium 15, fragrance mix I, and propylene glycol.
CONCLUSION
CONCLUSIONS
NE is a heterogeneous disorder with distinct subsets of lesional distributions and a profile of relevant allergens, especially formaldehyde and formaldehyde releasers. Nearly one in four patients with NE had ACD, supporting the role of patch testing in patients with NE.
Substances chimiques
Allergens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-57Informations de copyright
© 2021 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.
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