Pharmacological considerations for the treatment of COVID-19 in people living with HIV (PLWH).
COVID-19
DRV
FTC
IL-6 antagonists
LPV/r
SARS-CoV-2
TDF
cART
dexamethasone
interferon
remdesivir
Journal
Expert opinion on pharmacotherapy
ISSN: 1744-7666
Titre abrégé: Expert Opin Pharmacother
Pays: England
ID NLM: 100897346
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
pubmed:
27
2
2021
medline:
29
6
2021
entrez:
26
2
2021
Statut:
ppublish
Résumé
When coronavirus infectious disease-2019 (COVID-19) blew up, ill-fated auguries on the collision between COVID-19 and the human immunodeficiency virus (HIV) epidemics loomed. Data from observational studies suggest similar incidence attacks of SARS-CoV-2 infection in people living with HIV (PLWH) and HIV-uninfected populations. The mortality rate of COVID-19 is similar in both populations too. The authors discuss the role of combination antiretroviral therapy (cART) in preventing infection or reducing COVID-19 severity. They also discuss the pharmacological interventions for COVID-19 in PLWH. Management of COVID-19 in PLWH is no different from the general population. It should be based on careful supportive care, emphasizing lung-protective ventilation, and wise pharmacological interventions. The antiviral drug remdesivir and dexamethasone are the only pharmacological interventions with clinical benefit for COVID-19, whereas anticoagulation may prevent thrombotic complications. The experience with using these drugs in PLWH is limited, which prevents from rendering well-founded conclusions. Until more data on COVID-19 in PLWH become available, the best weapons within our reach are sound supportive care and sensible use of RDV and dexamethasone, bearing in mind the potential for drug-drug interactions of most corticosteroids and antiretroviral drugs.
Identifiants
pubmed: 33634724
doi: 10.1080/14656566.2021.1887140
pmc: PMC7919104
doi:
Substances chimiques
Anti-Retroviral Agents
0
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1127-1141Références
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