Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?

Humans Platelet Membrane Glycoproteins / pharmacology Structure-Activity Relationship
Dimerization GPVI Ligands Platelets Structure-function

Journal

Platelets
ISSN: 1369-1635
Titre abrégé: Platelets
Pays: England
ID NLM: 9208117

Informations de publication

Date de publication:
18 Aug 2021
Historique:
pubmed: 27 2 2021
medline: 29 12 2021
entrez: 26 2 2021
Statut: ppublish

Résumé

GPVI is a critical signaling receptor responsible for collagen-induced platelet activation and a promising anti-thrombotic target in conditions such as coronary artery thrombosis, ischemic stroke, and atherothrombosis. This is due to the ability to block GPVI while having minimal effects on hemostasis, making it a more attractive target over current dual-antiplatelet therapy (DAPT) with acetyl salicylic acid and P2Y

Identifiants

DOI: 10.1080/09537104.2021.1887469 PMID: 33634725
pubmed: 33634725
doi: 10.1080/09537104.2021.1887469
doi:

Substances chimiques

Platelet Membrane Glycoproteins 0
platelet membrane glycoprotein VI 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

724-732

Subventions

Organisme : British Heart Foundation
ID : CH/03/003/15571
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/18/30563
Pays : United Kingdom

Auteurs

Joanne C Clark (JC)

Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK.
ORCID: 0000-0002-1912-7816

Foteini-Nafsika Damaskinaki (FN)

Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK.
School of Pharmacy, Biodiscovery Institute, University Park, University of Nottingham, Nottingham, UK.

Yam Fung Hilaire Cheung (YFH)

Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Department of Bioanalytics, Leibniz-Institut Für Analytische Wissenschaften - ISAS -e.v, Dortmund, Germany.

Alexandre Slater (A)

Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
ORCID: 0000-0001-7166-438X

Steve P Watson (SP)

Institute of Cardiovascular Sciences, Level 1 IBR, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Centre of Membrane Proteins and Receptors (COMPARE), The Universities of Birmingham and Nottingham, The Midlands, UK.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-function relationship of the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Glycoprotéines de membrane plaquettaire › Structure-function relationship of the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure-function relationship of the...