Meta-analysis of adjuvant radiotherapy for intracranial atypical and malignant meningiomas.
Adjuvant
Atypical meningioma
High-grade meningioma
Malignant meningioma
Radiation therapy
Radiosurgery
Journal
Journal of neuro-oncology
ISSN: 1573-7373
Titre abrégé: J Neurooncol
Pays: United States
ID NLM: 8309335
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
23
09
2020
accepted:
05
12
2020
pubmed:
27
2
2021
medline:
17
11
2021
entrez:
26
2
2021
Statut:
ppublish
Résumé
Meningiomas comprise 33% of all CNS tumors. The World Health Organization (WHO) describes meningiomas as benign (BM), atypical (AM), and malignant/anaplastic (MM). High-grade meningiomas such as AMs and MMs are more aggressive, recur more frequently, and portend a worse prognosis than BMs. Currently, the standard treatment for high-grade meningiomas, especially AMs, is ill-defined. In particular, the benefit to survival outcomes of adjuvant radiotherapy post-surgical resection remains unclear. In this study, we investigated the effect of adjuvant radiotherapy (ART) post-surgery on survival outcomes compared to surgery alone for high-grade meningiomas. PRISMA guidelines were a foundation for our literature review. We screened the PubMed database for studies reporting overall survival (OS), progression free survival (PFS), and tumor recurrence for intracranial, primary AM and MMs treated with surgery+ART or surgery alone. Fixed and random effect models compared tumor control rate for AM aforementioned groups. Mean 5-year PFS was 76.9% for AM (surgery+ART) and 55.9% for AM (surgery alone) patients. Mean 5-year OS was 81.3% and 74% for AM (surgery+ART) and AM (surgery alone) groups, respectively. Overall, the mean 5-year PFS for aggregated high-grade meningiomas AM+MM (surgery+ART) was 67.6%. Fixed effect models revealed tumor control rate as 76% for AM (surgery+ART) and 69% for AM (surgery alone) groups. ART induced toxicity incidence ranged from 12.0% to 35.5% for AM and MM patients. Our analysis suggests that (surgery+ART) may increase PFS, OS, and tumor control rates in high-grade meningiomas. However, further studies involving surgery+ ART should be conducted to fully evaluate the ideal radiosurgical candidate, modality, and dosage.
Identifiants
pubmed: 33635510
doi: 10.1007/s11060-020-03674-7
pii: 10.1007/s11060-020-03674-7
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-216Références
Davis FG, Kupelian V, Freels S, McCarthy B, Surawicz T (2001) Prevalence estimates for primary brain tumors in the United States by behavior and major histology groups. Neuro-Oncology 3:152–158. https://doi.org/10.1093/neuonc/3.3.152
doi: 10.1093/neuonc/3.3.152
pubmed: 11465395
pmcid: 1920611
Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, Stroup NE, Kruchko C, Barnholtz-Sloan JS (2013) CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro-Oncology 15(Suppl 2):ii1–i56. https://doi.org/10.1093/neuonc/not151
doi: 10.1093/neuonc/not151
pubmed: 24137015
pmcid: 3798196
Dolecek TA, Dressler EV, Thakkar JP, Liu M, Al-Qaisi A, Villano JL (2015) Epidemiology of meningiomas post-Public Law 107–206: the benign brain tumor cancer registries amendment act. Cancer 121:2400–2410. https://doi.org/10.1002/cncr.29379
doi: 10.1002/cncr.29379
pubmed: 25872752
pmcid: 5549267
Buerki RA, Horbinski CM, Kruser T, Horowitz PM, James CD, Lukas RV (2018) An overview of meningiomas. Future Oncol 14:2161–2177. https://doi.org/10.2217/fon-2018-0006
doi: 10.2217/fon-2018-0006
pubmed: 30084265
pmcid: 6123887
Kaur G, Sayegh ET, Larson A, Bloch O, Madden M, Sun MZ, Barani IJ, James CD, Parsa AT (2014) Adjuvant radiotherapy for atypical and malignant meningiomas: a systematic review. Neuro-Oncology 16:628–636. https://doi.org/10.1093/neuonc/nou025
doi: 10.1093/neuonc/nou025
pubmed: 24696499
pmcid: 3984561
Mawrin C, Perry A (2010) Pathological classification and molecular genetics of meningiomas. J Neuro-Oncol 99:379–391. https://doi.org/10.1007/s11060-010-0342-2
doi: 10.1007/s11060-010-0342-2
Riemenschneider MJ, Perry A, Reifenberger G (2006) Histological classification and molecular genetics of meningiomas. Lancet Neurol 5:1045–1054. https://doi.org/10.1016/S1474-4422(06)70625-1
doi: 10.1016/S1474-4422(06)70625-1
pubmed: 17110285
Hwang KL, Hwang WL, Bussière MR, Shih HA (2017) The role of radiotherapy in the management of high-grade meningiomas. Chin Clin Oncol 6
Modha A, Gutin PH (2005) Diagnosis and treatment of atypical and anaplastic meningiomas: a review. Neurosurgery 57: 538–550; discussion 538–550 https://doi.org/10.1227/01.neu.0000170980.47582.a5
Goyal LK, Suh JH, Mohan DS, Prayson RA, Lee J, Barnett GH (2000) Local control and overall survival in atypical meningioma: a retrospective study. Int J Radiat Oncol Biol Phys 46:57–61. https://doi.org/10.1016/s0360-3016(99)00349-1
doi: 10.1016/s0360-3016(99)00349-1
pubmed: 10656373
Commins DL, Atkinson RD, Burnett ME (2007) Review of meningioma histopathology. Neurosurg Focus 23:E3. https://doi.org/10.3171/FOC-07/10/E3
doi: 10.3171/FOC-07/10/E3
pubmed: 17961040
Park HJ, Kang HC, Kim IH, Park SH, Kim DG, Park CK, Paek SH, Jung HW (2013) The role of adjuvant radiotherapy in atypical meningioma. J Neuro-Oncol 115:241–247. https://doi.org/10.1007/s11060-013-1219-y
doi: 10.1007/s11060-013-1219-y
Hug EB, Devries A, Thornton AF, Munzenride JE, Pardo FS, Hedley-Whyte ET, Bussiere MR, Ojemann R (2000) Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy. J Neuro-Oncol 48:151–160. https://doi.org/10.1023/a:1006434124794
doi: 10.1023/a:1006434124794
Bagshaw HP, Burt LM, Jensen RL, Suneja G, Palmer CA, Couldwell WT, Shrieve DC (2017) Adjuvant radiotherapy for atypical meningiomas. J Neurosurg 126:1822–1828. https://doi.org/10.3171/2016.5.JNS152809
doi: 10.3171/2016.5.JNS152809
pubmed: 27611201
Choi Y, Lim DH, Jo K, Nam DH, Seol HJ, Lee JI (2014) Efficacy of postoperative radiotherapy for high grade meningiomas. J Neuro-Oncol 119:405–412. https://doi.org/10.1007/s11060-014-1507-1
doi: 10.1007/s11060-014-1507-1
Harris AE, Lee JY, Omalu B, Flickinger JC, Kondziolka D, Lunsford LD (2003) The effect of radiosurgery during management of aggressive meningiomas. Surg Neurol 60: 298–305; discussion 305. https://doi.org/10.1016/s0090-3019(03)00320-3
Kano H, Takahashi JA, Katsuki T, Araki N, Oya N, Hiraoka M, Hashimoto N (2007) Stereotactic radiosurgery for atypical and anaplastic meningiomas. J Neuro-Oncol 84:41–47. https://doi.org/10.1007/s11060-007-9338-y
doi: 10.1007/s11060-007-9338-y
Detti B, Scoccianti S, Di Cataldo V, Monteleone E, Cipressi S, Bordi L, Pellicano G, Gadda D, Saieva C, Greto D, Pecchioli G, Buccoliero A, Ceroti M, Ammannati F, Biti G (2013) Atypical and malignant meningioma: outcome and prognostic factors in 68 irradiated patients. J Neuro-Oncol 115:421–427. https://doi.org/10.1007/s11060-013-1239-7
doi: 10.1007/s11060-013-1239-7
Chen WC, Magill ST, Wu A, Vasudevan HN, Morin O, Aghi MK, Theodosopoulos PV, Perry A, McDermott MW, Sneed PK, Braunstein SE, Raleigh DR (2018) Histopathological features predictive of local control of atypical meningioma after surgery and adjuvant radiotherapy. J Neurosurg 130:443–450. https://doi.org/10.3171/2017.9.JNS171609
doi: 10.3171/2017.9.JNS171609
pubmed: 29624151
Dohm A, McTyre ER, Chan MD, Fan C, Isom S, Bourland JD, Mott RT, Cramer CK, Tatter SB, Laxton AW (2017) Early or late radiotherapy following gross or subtotal resection for atypical meningiomas: Clinical outcomes and local control. J Clin Neurosci 46:90–98. https://doi.org/10.1016/j.jocn.2017.08.023
doi: 10.1016/j.jocn.2017.08.023
pubmed: 28917587
pmcid: 5693228
Masalha W, Heiland DH, Franco P, Delev D, Haaker JG, Schnell O, Scheiwe C, Grauvogel J (2018) Atypical meningioma: progression-free survival in 161 cases treated at our institution with surgery versus surgery and radiotherapy. J Neuro-Oncol 136:147–154. https://doi.org/10.1007/s11060-017-2634-2
doi: 10.1007/s11060-017-2634-2
Lubgan D, Rutzner S, Lambrecht U, Rossler K, Buchfelder M, Eyupoglu I, Fietkau R, Semrau S (2017) Stereotactic radiotherapy as primary definitive or postoperative treatment of intracranial meningioma of WHO grade II and III leads to better disease control than stereotactic radiotherapy of recurrent meningioma. J Neuro-Oncol 134:407–416. https://doi.org/10.1007/s11060-017-2540-7
doi: 10.1007/s11060-017-2540-7
Weber DC, Ares C, Villa S, Peerdeman SM, Renard L, Baumert BG, Lucas A, Veninga T, Pica A, Jefferies S, Ricardi U, Miralbell R, Stelmes JJ, Liu Y, Collette L, Collette S (2018) Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: a phase-II parallel non-randomized and observation study (EORTC 22042-26042). Radiother Oncol 128:260–265. https://doi.org/10.1016/j.radonc.2018.06.018
doi: 10.1016/j.radonc.2018.06.018
pubmed: 29960684
Aghi MK, Carter BS, Cosgrove GR, Ojemann RG, Amin-Hanjani S, Martuza RL, Curry WT, Jr., Barker FG, 2nd (2009) Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiation. Neurosurgery 64: 56–60; discussion 60. https://doi.org/10.1227/01.NEU.0000330399.55586.63
Hammouche S, Clark S, Wong AH, Eldridge P, Farah JO (2014) Long-term survival analysis of atypical meningiomas: survival rates, prognostic factors, operative and radiotherapy treatment. Acta Neurochir 156:1475–1481. https://doi.org/10.1007/s00701-014-2156-z
doi: 10.1007/s00701-014-2156-z
pubmed: 24965072
Kaul D, Budach V, Wurm R, Gruen A, Graaf L, Habbel P, Badakhshi H (2014) Linac-based stereotactic radiotherapy and radiosurgery in patients with meningioma. Radiat Oncol 9:78. https://doi.org/10.1186/1748-717X-9-78
doi: 10.1186/1748-717X-9-78
pubmed: 24650090
pmcid: 4028108
Zhi M, Girvigian MR, Miller MJ, Chen JC, Schumacher AJ, Rahimian J, Lodin K (2019) Long-term outcomes of newly diagnosed resected atypical meningiomas and the role of adjuvant radiotherapy. World Neurosurg 122:e1153–e1161. https://doi.org/10.1016/j.wneu.2018.11.006
doi: 10.1016/j.wneu.2018.11.006
pubmed: 30447464
Dziuk TW, Woo S, Butler EB, Thornby J, Grossman R, Dennis WS, Lu H, Carpenter LS, Chiu JK (1998) Malignant meningioma: an indication for initial aggressive surgery and adjuvant radiotherapy. J Neuro-Oncol 37:177–188. https://doi.org/10.1023/a:1005853720926
doi: 10.1023/a:1005853720926
Cain SA, Smoll NR, Van Heerden J, Tsui A, Drummond KJ (2015) Atypical and malignant meningiomas: Considerations for treatment and efficacy of radiotherapy. J Clin Neurosci 22:1742–1748. https://doi.org/10.1016/j.jocn.2015.03.054
doi: 10.1016/j.jocn.2015.03.054
pubmed: 26213286
Durand A, Labrousse F, Jouvet A, Bauchet L, Kalamarides M, Menei P, Deruty R, Moreau JJ, Fevre-Montange M, Guyotat J (2009) WHO grade II and III meningiomas: a study of prognostic factors. J Neuro-Oncol 95:367–375. https://doi.org/10.1007/s11060-009-9934-0
doi: 10.1007/s11060-009-9934-0
Yang SY, Park CK, Park SH, Kim DG, Chung YS, Jung HW (2008) Atypical and anaplastic meningiomas: prognostic implications of clinicopathological features. J Neurol Neurosurg Psychiatry 79:574–580. https://doi.org/10.1136/jnnp.2007.121582
doi: 10.1136/jnnp.2007.121582
pubmed: 17766430
Rosenberg LA, Prayson RA, Lee J, Reddy C, Chao ST, Barnett GH, Vogelbaum MA, Suh JH (2009) Long-term experience with World Health Organization grade III (malignant) meningiomas at a single institution. Int J Radiat Oncol Biol Phys 74:427–432. https://doi.org/10.1016/j.ijrobp.2008.08.018
doi: 10.1016/j.ijrobp.2008.08.018
pubmed: 19427553
Zhao P, Hu M, Zhao M, Ren X, Jiang Z (2015) Prognostic factors for patients with atypical or malignant meningiomas treated at a single center. Neurosurg Rev 38:101–107. https://doi.org/10.1007/s10143-014-0558-2
doi: 10.1007/s10143-014-0558-2
pubmed: 25139398
El-Khatib M, El Majdoub F, Hoevels M, Kocher M, Müller RP, Steiger HJ, Sturm V, Maarouf M (2011) Stereotactic LINAC radiosurgery for incompletely resected or recurrent atypical and anaplastic meningiomas. Acta Neurochir 153:1761–1767. https://doi.org/10.1007/s00701-011-1073-7
doi: 10.1007/s00701-011-1073-7
pubmed: 21706274
Noël G, Bollet MA, Calugaru V, Feuvret L, Haie-Meder C, Dhermain F, Ferrand R, Boisserie G, Beaudré A, Mazeron J-J, Habrand J-L (2005) Functional outcome of patients with benign meningioma treated by 3D conformal irradiation with a combination of photons and protons. Int J Radiat Oncol Biol Phys 62:1412–1422. https://doi.org/10.1016/j.ijrobp.2004.12.048
doi: 10.1016/j.ijrobp.2004.12.048
pubmed: 16029801
van Nieuwenhuizen D, Klein M, Stalpers LJA, Leenstra S, Heimans JJ, Reijneveld JC (2007) Differential effect of surgery and radiotherapy on neurocognitive functioning and health-related quality of life in WHO grade I meningioma patients. J Neuro-Oncol 84:271–278. https://doi.org/10.1007/s11060-007-9366-7
doi: 10.1007/s11060-007-9366-7
Morgenstern PF, Shah K, Dunkel IJ, Reiner AS, Khakoo Y, Rosenblum MK, Gutin P (2016) Meningioma after radiotherapy for malignancy. J Clin Neurosci 30:93–97. https://doi.org/10.1016/j.jocn.2016.02.002
doi: 10.1016/j.jocn.2016.02.002
pubmed: 27068012
pmcid: 5407008
Nicolato A, Foroni R, Pellegrino M, Ferraresi P, Alessandrini F, Gerosa M, Bricolo A (2001) Gamma knife radiosurgery in meningiomas of the posterior fossa. Experience with 62 treated lesions. Minim Invasive Neurosurg 44:211–217. https://doi.org/10.1055/s-2001-19934
doi: 10.1055/s-2001-19934
pubmed: 11830780
Sheehan JP, Cohen-Inbar O, Ruangkanchanasetr R, Bulent Omay S, Hess J, Chiang V, Iorio-Morin C, Alonso-Basanta M, Mathieu D, Grills IS, Lee JY, Lee CC, Dade Lunsford L (2015) Post-radiosurgical edema associated with parasagittal and parafalcine meningiomas: a multicenter study. J Neuro-Oncol 125:317–324. https://doi.org/10.1007/s11060-015-1911-1
doi: 10.1007/s11060-015-1911-1
Sheehan JP, Starke RM, Kano H, Barnett GH, Mathieu D, Chiang V, Yu JB, Hess J, McBride HL, Honea N, Nakaji P, Lee JY, Rahmathulla G, Evanoff WA, Alonso-Basanta M, Lunsford LD (2015) Gamma Knife radiosurgery for posterior fossa meningiomas: a multicenter study. J Neurosurg 122:1479–1489. https://doi.org/10.3171/2014.10.JNS14139
doi: 10.3171/2014.10.JNS14139
pubmed: 25859812
Prasad RN, Breneman JC, Struve T, Warnick RE, Pater LE (2018) Linac-based fractionated stereotactic radiosurgery for high-risk meningioma. J Radiosurg SBRT 5:269–276
pubmed: 30538887
pmcid: 6255720
Unger KR, Lominska CE, Chanyasulkit J, Randolph-Jackson P, White RL, Aulisi E, Jacobson J, Jean W, Gagnon GJ (2012) Risk factors for posttreatment edema in patients treated with stereotactic radiosurgery for meningiomas. Neurosurgery 70:639–645. https://doi.org/10.1227/NEU.0b013e3182351ae7
doi: 10.1227/NEU.0b013e3182351ae7
pubmed: 21904263
Kondziolka D, Mathieu D, Lunsford LD, Martin JJ, Madhok R, Niranjan A, Flickinger JC (2008) Radiosurgery as definitive management of intracranial meningiomas. Neurosurgery 62: 53–58; discussion 58–60. https://doi.org/10.1227/01.NEU.0000311061.72626.0D
Minniti G, Amichetti M, Enrici RM (2009) Radiotherapy and radiosurgery for benign skull base meningiomas. Radiat Oncol 4:42. https://doi.org/10.1186/1748-717X-4-42
doi: 10.1186/1748-717X-4-42
pubmed: 19828022
pmcid: 2768735
Morimoto M, Yoshioka Y, Shiomi H, Isohashi F, Konishi K, Kotsuma T, Fukuda S, Kagawa N, Kinoshita M, Hashimoto N, Yoshimine T, Koizumi M (2011) Significance of tumor volume related to peritumoral edema in intracranial meningioma treated with extreme hypofractionated stereotactic radiation therapy in three to five fractions. Jpn J Clin Oncol 41:609–616. https://doi.org/10.1093/jjco/hyr022
doi: 10.1093/jjco/hyr022
pubmed: 21411468
Oermann EK, Bhandari R, Chen VJ, Lebec G, Gurka M, Lei S, Chen L, Suy S, Azumi N, Berkowitz F, Kalhorn C, McGrail K, Collins BT, Jean WC, Collins SP (2013) Five fraction image-guided radiosurgery for primary and recurrent meningiomas. Front Oncol 3:213. https://doi.org/10.3389/fonc.2013.00213
doi: 10.3389/fonc.2013.00213
pubmed: 23971006
pmcid: 3747443
McTyre E, Helis CA, Farris M, Wilkins L, Sloan D, Hinson WH, Bourland JD, Dezarn WA, Munley MT, Watabe K, Xing F, Laxton AW, Tatter SB, Chan MD (2017) Emerging indications for fractionated gamma knife radiosurgery. Neurosurgery 80:210–216. https://doi.org/10.1227/NEU.0000000000001227
doi: 10.1227/NEU.0000000000001227
pubmed: 28536486
pmcid: 5017892
Kirkpatrick JP, Soltys SG, Lo SS, Beal K, Shrieve DC, Brown PD (2017) The radiosurgery fractionation quandary: single fraction or hypofractionation? Neuro-Oncology 19:ii38–ii49. https://doi.org/10.1093/neuonc/now301
doi: 10.1093/neuonc/now301
pubmed: 28380634
pmcid: 5463582
Rogers L, Barani I, Chamberlain M, Kaley TJ, McDermott M, Raizer J, Schiff D, Weber DC, Wen PY, Vogelbaum MA (2015) Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. J Neurosurg 122:4–23. https://doi.org/10.3171/2014.7.JNS131644
doi: 10.3171/2014.7.JNS131644
pubmed: 25343186
pmcid: 5062955
Endo T, Narisawa A, Ali HS, Murakami K, Watanabe T, Watanabe M, Jokura H, Endo H, Fujimura M, Sonoda Y, Tominaga T (2016) A study of prognostic factors in 45 cases of atypical meningioma. Acta Neurochir 158:1661–1667. https://doi.org/10.1007/s00701-016-2900-7
doi: 10.1007/s00701-016-2900-7
pubmed: 27468919