BDNF serum concentrations in 2053 participants of the Berlin Aging Study II.
Aging
Brain-derived neurotrophic factor
Depression
Platelet
Journal
Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
18
05
2020
revised:
30
08
2020
accepted:
25
01
2021
pubmed:
27
2
2021
medline:
1
12
2021
entrez:
26
2
2021
Statut:
ppublish
Résumé
Serum BDNF concentrations in 2053 participants of the Berlin Aging Study II (BASE-II; 1572 individuals from the older age group [60-85 years], 481 individuals from the younger-age reference group [22-37 years]) were studied. There was no effect of age, sex, body mass index, self-reported depression, or BDNF Val66Met variant on serum BDNF concentrations. Multiple linear regression analysis failed to detect significant relationships of Digit Symbol Substitution Test score and Consortium to Establish a Registry for Alzheimer's Disease memory score to BDNF levels. However, we detected a positive correlation between platelet counts and BDNF levels (r = 0.303, p < 0.001). Our findings do not support an effect of aging, self-reported depression, or the Val66Met variant on serum BDNF concentrations. The role of thrombocytes in the biology of serum BDNF merits further study.
Identifiants
pubmed: 33636574
pii: S0197-4580(21)00027-0
doi: 10.1016/j.neurobiolaging.2021.01.020
pii:
doi:
Substances chimiques
Biomarkers
0
Brain-Derived Neurotrophic Factor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-223Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure statement The authors declare no competing interests.