Rationale and design of the Kidney Precision Medicine Project.

Acute Kidney Injury / diagnosis Adult Humans Kidney Precision Medicine Prospective Studies Proteomics Renal Insufficiency, Chronic / diagnosis
acute kidney injury chronic kidney disease diabetes hypertension precision medicine

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
03 2021
Historique:
received: 22 06 2020
revised: 08 08 2020
accepted: 14 08 2020
entrez: 27 2 2021
pubmed: 28 2 2021
medline: 22 6 2021
Statut: ppublish

Résumé

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

Identifiants

DOI: 10.1016/j.kint.2020.08.039 PMID: 33637194 PMC: PMC8330551
pubmed: 33637194
pii: S0085-2538(20)31403-4
doi: 10.1016/j.kint.2020.08.039
pmc: PMC8330551
mid: NIHMS1698554
pii:
doi:

Types de publication

Editorial Multicenter Study Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

498-510

Subventions

Organisme : NIDDK NIH HHS
ID : UH3 DK114907
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK107864
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114908
Pays : United States
Organisme : NIDDK NIH HHS
ID : U2C DK114886
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114915
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114920
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114861
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079312
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114866
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114933
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK114886
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114923
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114926
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114937
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK114870
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK114907
Pays : United States

Investigateurs

Richard Knight (R)
Stewart Lecker (S)
Isaac Stillman (I)
Sushrut Waikar (S)
Gearoid Mcmahon (G)
Astrid Weins (A)
Samuel Short (S)
Nir Hacohen (N)
Paul Hoover (P)
Mark Aulisio (M)
Leslie Cooperman (L)
Leal Herlitz (L)
John O'Toole (J)
Emilio Poggio (E)
John Sedor (J)
Stacey Jolly (S)
Paul Appelbaum (P)
Olivia Balderes (O)
Jonathan Barasch (J)
Andrew Bomback (A)
Pietro A Canetta (PA)
Vivette D d'Agati (VD)
Krzysztof Kiryluk (K)
Satoru Kudose (S)
Karla Mehl (K)
Jai Radhakrishnan (J)
Chenhua Weng (C)
Laura Barisoni (L)
Theodore Alexandrov (T)
Tarek Ashkar (T)
Daria Barwinska (D)
Pierre Dagher (P)
Kenneth Dunn (K)
Michael Eadon (M)
Michael Ferkowicz (M)
Katherine Kelly (K)
Timothy Sutton (T)
Seth Winfree (S)
Steven Menez (S)
Chirag Parikh (C)
Avi Rosenberg (A)
Pam Villalobos (P)
Rubab Malik (R)
Derek Fine (D)
Mohammed Atta (M)
Jose Manuel Monroy Trujillo (JM)
Alison Slack (A)
Sylvia Rosas (S)
Mark Williams (M)
Evren Azeloglu (E)
Cijang John He (CJ)
Ravi Iyengar (R)
Jens Hansen (J)
Samir Parikh (S)
Brad Rovin (B)
Chris Anderton (C)
Ljiljana Pasa-Tolic (L)
Dusan Velickovic (D)
Jessica Lukowski (J)
George Holt Oliver (GH)
Joseph Ardayfio (J)
Jack Bebiak (J)
Keith Brown (K)
Taneisha Campbell (T)
Catherine Campbell (C)
Lynda Hayashi (L)
Nichole Jefferson (N)
Robert Koewler (R)
Glenda Roberts (G)
John Saul (J)
Anna Shpigel (A)
Edith Christine Stutzke (EC)
Lorenda Wright (L)
Leslie Miegs (L)
Roy Pinkeney (R)
Rachel Sealfon (R)
Olga Troyanskaya (O)
Katherine Tuttle (K)
Dejan Dobi (D)
Yury Goltsev (Y)
Blue Lake (B)
Kun Zhang (K)
Maria Joanes (M)
Zoltan Laszik (Z)
Andrew Schroeder (A)
Minnie Sarwal (M)
Tara Sigdel (T)
Ulysses Balis (U)
Victoria Blanc (V)
Oliver He (O)
Jeffrey Hodgin (J)
Matthias Kretzler (M)
Laura Mariani (L)
Rajasree Menon (R)
Edgar Otto (E)
Jennifer Schaub (J)
Becky Steck (B)
Chrysta Lienczewski (C)
Sean Eddy (S)
Michele Elder (M)
Daniel Hall (D)
John Kellum (J)
Mary Kruth (M)
Raghav Murugan (R)
Paul Palevsky (P)
Parmjeet Randhawa (P)
Matthew Rosengart (M)
Sunny Sims-Lucas (S)
Mary Stefanick (M)
Stacy Stull (S)
Mitchell Tublin (M)
Charles Alpers (C)
Ian de Boer (I)
Ashveena Dighe (A)
Jonathan Himmelfarb (J)
Robyn Mcclelland (R)
Sean Mooney (S)
Stuart Shankland (S)
Kayleen Williams (K)
Kristina Blank (K)
Jonas Carson (J)
Frederick Dowd (F)
Zach Drager (Z)
Christopher Park (C)
Kumar Sharma (K)
Guanshi Zhang (G)
Shweta Bansal (S)
Manjeri Venkatachalam (M)
Asra Kermani (A)
Simon Lee (S)
Christopher Lu (C)
Tyler Miller (T)
Orson Moe (O)
Harold Park (H)
Kamalanathan Sambandam (K)
Francisco Sanchez (F)
Jose Torrealba (J)
Toto Robert (T)
Miguel Vazquez (M)
Nancy Wang (N)
Joe Gaut (J)
Sanjay Jain (S)
Anitha Vijayan (A)
Randy Luciano (R)
Dennis Moledina (D)
Ugwuowo Ugochukwu (U)
Francis Perry Wilson (FP)
Sandy Alfano (S)

Informations de copyright

Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

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Auteurs

Ian H de Boer (IH)

Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address: deboer@u.washington.edu.

Charles E Alpers (CE)

Department of Pathology, University of Washington, Seattle, Washington, USA.

Evren U Azeloglu (EU)

Department of Medicine, Icahn School of Medicine at Mt. Sinai, New York, New York, USA.

Ulysses G J Balis (UGJ)

Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

Jonathan M Barasch (JM)

Department of Pathology, Columbia University, New York, New York, USA.

Laura Barisoni (L)

Department of Pathology, Duke University, Durham, North Carolina, USA.

Kristina N Blank (KN)

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

Andrew S Bomback (AS)

Department of Medicine, Columbia University, New York, New York, USA.

Keith Brown (K)

Patient Representative, Kidney Precision Medicine Project Steering Committee Member.

Pierre C Dagher (PC)

Department of Medicine, Indiana University, Indianapolis, Indiana, USA.

Ashveena L Dighe (AL)

Department of Medicine, University of Washington, Seattle, Washington, USA.

Michael T Eadon (MT)

Department of Medicine, Indiana University, Indianapolis, Indiana, USA.

Tarek M El-Achkar (TM)

Department of Medicine, Indiana University, Indianapolis, Indiana, USA.

Joseph P Gaut (JP)

Department of Pathology, Washington University School of Medicine, St. Louis, St. Louis, Missouri, USA.

Nir Hacohen (N)

Broad Institute, Cambridge, Massachusetts, USA.

Yongqun He (Y)

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.

Jeffrey B Hodgin (JB)

Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

Sanjay Jain (S)

Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, Missouri, USA.

John A Kellum (JA)

Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Krzysztof Kiryluk (K)

Department of Medicine, Columbia University, New York, New York, USA.

Richard Knight (R)

American Association of Kidney Patients, Kidney Precision Medicine Project Patient Partner.

Zoltan G Laszik (ZG)

Department of Pathology, University of California, San Francisco, San Francisco, California, USA.

Chrysta Lienczewski (C)

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Laura H Mariani (LH)

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Robyn L McClelland (RL)

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

Steven Menez (S)

Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.

Dennis G Moledina (DG)

Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.

Sean D Mooney (SD)

Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA.

John F O'Toole (JF)

Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.

Paul M Palevsky (PM)

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Renal Section, Veterans Administration Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, USA.

Chirag R Parikh (CR)

Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.

Emilio D Poggio (ED)

Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.

Sylvia E Rosas (SE)

Joslin Diabetes Center, Boston, Massachusetts, USA.

Matthew R Rosengart (MR)

Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Minnie M Sarwal (MM)

Department of Surgery, University of California, San Francisco, San Francisco, California, USA.

Jennifer A Schaub (JA)

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

John R Sedor (JR)

Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.

Kumar Sharma (K)

Department of Medicine, UT Health San Antonio, San Antonio, Texas, USA.

Becky Steck (B)

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Robert D Toto (RD)

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.

Olga G Troyanskaya (OG)

Department of Computer Science, Princeton University, Princeton, New Jersey, USA.

Katherine R Tuttle (KR)

Department of Medicine, University of Washington, Seattle, Washington, USA.

Miguel A Vazquez (MA)

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.

Sushrut S Waikar (SS)

Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA.

Kayleen Williams (K)

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

Francis Perry Wilson (FP)

Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.

Kun Zhang (K)

Institute for Genomic Sciences, University of California, San Diego, California, USA.

Ravi Iyengar (R)

Mount Sinai Institute for Systems Biomedicine, Mount Sinai, New York, New York, USA.

Matthias Kretzler (M)

Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Jonathan Himmelfarb (J)

Department of Medicine, University of Washington, Seattle, Washington, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › Rationale and design of the Kidney Precision...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Rationale and design of the Kidney Precision...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rationale and design of the Kidney Precision...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Rationale and design of the Kidney Precision...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Rationale and design of the Kidney Precision...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Rationale and design of the Kidney Precision...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Rationale and design of the Kidney Precision...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Rationale and design of the Kidney Precision...