COVID-19 in a cohort of pregnant women and their descendants, the MOACC-19 study.
COVID-19
/ diagnosis
COVID-19 Nucleic Acid Testing
COVID-19 Serological Testing
Female
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical
Pandemics
Pregnancy
Pregnancy Complications, Infectious
/ epidemiology
Prospective Studies
RNA, Viral
/ isolation & purification
Retrospective Studies
SARS-CoV-2
/ genetics
Spain
/ epidemiology
epidemiology
maternal medicine
paediatric infectious disease & immunisation
public health
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
26 02 2021
26 02 2021
Historique:
entrez:
27
2
2021
pubmed:
28
2
2021
medline:
5
3
2021
Statut:
epublish
Résumé
The Mother and Child COVID-19 study is a cohort recruiting pregnant women and their children in Cantabria, North of Spain, during COVID-19 pandemic in order to ascertain consequences of SARS-CoV-2 infection on pregnant women and their descendants. This article reports the cohort profile and preliminary results as recruitment is still open. Three subcohorts can be identified at recruitment. Subcohort 1 includes women giving birth between 23 March and 25 May 2020; they have been retrospectively recruited and could have been exposed to COVID-19 only in their third trimester of pregnancy. Subcohort 2 includes women giving birth from 26 May 2020 on; they are being prospectively recruited and could have been exposed to COVID-19 in both their second and third trimesters of pregnancy. Subcohort 3 includes women in their 12 week of pregnancy prospectively recruited from 26 May 2020 on; they could have been exposed to COVID-19 anytime in their pregnancy. All women are being tested for SARS-CoV-2 infection using both RT-PCR for RNA detection and ELISA for anti-SARS-CoV-2 antibodies. All neonates are being tested for antibodies using immunochemoluminiscency tests; if the mother is tested positive for SARS-CoV-2 RNA, a nasopharyngeal swab is also obtained from the child for RT-PCR analysis. As of 22 October, 1167 women have been recruited (266, 354 and 547 for subcohorts 1, 2 and 3, respectively). Fourteen women tested positive to SARS-CoV-2 RNA by the day of delivery. All 14 children born from these women tested negative for SARS-CoV-2 RNA. Children from women included in subcohort 3 are expected to be recruited by the end of 2020. Children will be followed-up for 1 year in order to ascertain the effect that COVID-19 on their development.
Identifiants
pubmed: 33637549
pii: bmjopen-2020-044224
doi: 10.1136/bmjopen-2020-044224
pmc: PMC7918808
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e044224Investigateurs
Jéssica Alonso-Molero
(J)
Bárbara Arozamena
(B)
Laura Conde-Gil
(L)
Elsa Cornejo Del Río
(ECD)
Rocío Cuesta-González
(R)
Trinidad Dierssen-Sotos
(T)
Pelayo Frank de Zulueta
(PF)
Inés Gómez-Acebo
(I)
Coral Llano-Ruiz
(C)
Lorena Lasarte-Oria
(L)
Sonia López-Gómez
(S)
Sonia Mateo-Sota
(S)
Victoria Orallo
(V)
Rosa Pardo
(R)
Daniel Pérez González
(DP)
María Sáez de Adana Herrero
(MS)
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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