Ultra-processed food targets bone quality via endochondral ossification.
Journal
Bone research
ISSN: 2095-4700
Titre abrégé: Bone Res
Pays: China
ID NLM: 101608652
Informations de publication
Date de publication:
26 Feb 2021
26 Feb 2021
Historique:
received:
11
05
2020
accepted:
01
11
2020
revised:
11
10
2020
entrez:
27
2
2021
pubmed:
28
2
2021
medline:
28
2
2021
Statut:
epublish
Résumé
Ultra-processed foods have known negative implications for health; however, their effect on skeletal development has never been explored. Here, we show that young rats fed ultra-processed food rich in fat and sugar suffer from growth retardation due to lesions in their tibial growth plates. The bone mineral density decreases significantly, and the structural parameters of the bone deteriorate, presenting a sieve-like appearance in the cortices and poor trabecular parameters in long bones and vertebrae. This results in inferior mechanical performance of the entire bone with a high fracture risk. RNA sequence analysis of the growth plates demonstrated an imbalance in extracellular matrix formation and degradation and impairment of proliferation, differentiation and mineralization processes. Our findings highlight, for the first time, the severe impact of consuming ultra-processed foods on the growing skeleton. This pathology extends far beyond that explained by the known metabolic effects, highlighting bone as a new target for studies of modern diets.
Identifiants
pubmed: 33637698
doi: 10.1038/s41413-020-00127-9
pii: 10.1038/s41413-020-00127-9
pmc: PMC7910299
doi:
Types de publication
Journal Article
Langues
eng
Pagination
14Subventions
Organisme : Israel Science Foundation (ISF)
ID : 1050/13
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