To Curb the Progression of Fatal COVID-19 Course-Dream or Reality.
ACEI/ARB
COVID-19
Glycocalyx
Heparin
Spironolactone
Journal
Current hypertension reports
ISSN: 1534-3111
Titre abrégé: Curr Hypertens Rep
Pays: United States
ID NLM: 100888982
Informations de publication
Date de publication:
27 02 2021
27 02 2021
Historique:
accepted:
26
01
2021
entrez:
27
2
2021
pubmed:
28
2
2021
medline:
5
3
2021
Statut:
epublish
Résumé
To analyze the impact of sodium retention states on the course of COVID-19 and propose possible interventions to curb disease progression. Numerous data confirm a positive association of non-communicable diseases, aging, and other sodium-retaining states, including iatrogenic ones, with more severe sometimes fatal clinical course of COVID-19. Reasons for this effect could include increased angiotensin signaling via the AT1R receptor. The endothelial glycocalyx also plays an important role in infection, leading to a vicious cycle of inflammation and tissue sodium retention when damaged. RAS inhibitors may help restore glycocalyx function and prevent severe organ damage. Anticoagulants, especially heparin, may also have therapeutic applications due to antithrombotic, anti-inflammatory, glycocalyx-repairing, and antialdosteronic properties. The ambiguous influence of some diuretics on sodium balance was also discussed. Abnormal sodium storage and increased angiotensin-converting enzyme activity are related to the severity of COVID-19. Inducing sodium removal and reducing intake might improve outcomes.
Identifiants
pubmed: 33638064
doi: 10.1007/s11906-021-01130-z
pii: 10.1007/s11906-021-01130-z
pmc: PMC7910199
doi:
Substances chimiques
Angiotensin Receptor Antagonists
0
Angiotensin-Converting Enzyme Inhibitors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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