A single QTL with large effect is associated with female functional virginity in an asexual parasitoid wasp.
asexuality
candidate genes
female functional virginity
introgression
linkage map
loss of sex
resistance to mating
single major QTL
Journal
Molecular ecology
ISSN: 1365-294X
Titre abrégé: Mol Ecol
Pays: England
ID NLM: 9214478
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
07
02
2021
received:
06
11
2020
accepted:
22
02
2021
pubmed:
28
2
2021
medline:
22
6
2021
entrez:
27
2
2021
Statut:
ppublish
Résumé
During the transition from sexual to asexual reproduction, a suite of reproduction-related sexual traits become superfluous, and may be selected against if costly. Female functional virginity refers to asexual females resisting to mate or not fertilizing eggs after mating. These traits appear to be among the first that evolve during transitions from sexual to asexual reproduction. The genetic basis of female functional virginity remains elusive. Previously, we reported that female functional virginity segregates as expected for a single recessive locus in the asexual parasitoid wasp Asobara japonica. Here, we investigate the genetic basis of this trait by quantitative trait loci (QTL) mapping and candidate gene analyses. Consistent with the segregation of phenotypes, we found a single QTL of large effect, spanning over 4.23 Mb and comprising at least 131 protein-coding genes, of which 15 featured sex-biased expression in the related sexual species Asobara tabida. Two of the 15 sex-biased genes were previously identified to differ between related sexual and asexual population/species: CD151 antigen and nuclear pore complex protein Nup50. A third gene, hormone receptor 4, is involved in steroid hormone mediated mating behaviour. Overall, our results are consistent with a single locus, or a cluster of closely linked loci, underlying rapid evolution of female functional virginity in the transition to asexuality. Once this variant, causing rejection to mate, has swept through a population, the flanking region does not get smaller owing to lack of recombination in asexuals.
Identifiants
pubmed: 33638236
doi: 10.1111/mec.15863
pmc: PMC8252104
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1979-1992Informations de copyright
© 2021 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.
Références
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
J Evol Biol. 2005 Jul;18(4):1019-28
pubmed: 16033575
PLoS Genet. 2019 Aug 14;15(8):e1008331
pubmed: 31412019
BMC Evol Biol. 2015 May 12;15:84
pubmed: 25963738
Sex Dev. 2014;8(1-3):59-73
pubmed: 24355929
Gigascience. 2019 Sep 1;8(9):
pubmed: 31544214
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16353-8
pubmed: 25368171
Bioinformatics. 2013 Apr 15;29(8):1072-5
pubmed: 23422339
Heredity (Edinb). 2012 Mar;108(3):341-6
pubmed: 21934703
Nucleic Acids Res. 1997 Nov 15;25(22):4692-3
pubmed: 9358185
Heredity (Edinb). 2011 Jan;106(1):58-67
pubmed: 20442735
Curr Biol. 1999 Mar 25;9(6):313-6
pubmed: 10209097
Bioinformatics. 2017 Jul 15;33(14):2202-2204
pubmed: 28369201
Appl Environ Microbiol. 2010 Apr;76(8):2589-99
pubmed: 20173065
Genome Biol Evol. 2016 Dec 1;8(12):3685-3695
pubmed: 28172869
Nucleic Acids Res. 2012 May;40(10):4288-97
pubmed: 22287627
Proc Natl Acad Sci U S A. 2001 May 22;98(11):6247-52
pubmed: 11353833
Heredity (Edinb). 2009 Jul;103(1):15-22
pubmed: 19259113
PLoS One. 2013 Apr 02;8(4):e60459
pubmed: 23637750
PLoS One. 2015 Jul 15;10(7):e0132628
pubmed: 26177194
Bioinformatics. 2003 May 1;19(7):889-90
pubmed: 12724300
Bioinformatics. 2016 Jun 1;32(11):1749-51
pubmed: 26826718
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
BMC Biol. 2010 Jul 28;8:101
pubmed: 20687906
Nat Biotechnol. 2016 May;34(5):525-7
pubmed: 27043002
Nat Rev Microbiol. 2008 Oct;6(10):741-51
pubmed: 18794912
Nucleic Acids Res. 2008 Jun;36(10):3420-35
pubmed: 18445632
Science. 1982 Oct 1;218(4567):68-70
pubmed: 17776711
Evolution. 2009 Dec;63(12):3085-96
pubmed: 19659591
Heredity (Edinb). 2009 Sep;103(3):248-56
pubmed: 19513092
Genetics. 2004 May;167(1):253-62
pubmed: 15166152
Gigascience. 2015 Mar 18;4:10
pubmed: 25789164
Bioinformatics. 2015 Oct 1;31(19):3210-2
pubmed: 26059717
Biol Rev Camb Philos Soc. 2014 Nov;89(4):805-19
pubmed: 24443922
Naturwissenschaften. 2011 Mar;98(3):175-80
pubmed: 21221516
Methods. 2012 Nov;58(3):268-76
pubmed: 22652625
Science. 1933 Dec 8;78(2032):537-8
pubmed: 17836768
F1000Res. 2016 Jun 20;5:1438
pubmed: 27508061
Front Cell Dev Biol. 2017 Apr 06;5:34
pubmed: 28428953
Insects. 2012 Feb 10;3(1):161-99
pubmed: 26467955
Annu Rev Entomol. 1997;42:587-609
pubmed: 15012323
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
PLoS Biol. 2011 Sep;9(9):e1001160
pubmed: 21980261
Genome Biol. 2018 Oct 5;19(1):156
pubmed: 30290841
J Evol Biol. 2012 Sep;25(9):1718-31
pubmed: 22694106
Bioinformatics. 2005 May 1;21(9):1859-75
pubmed: 15728110
Mol Biol Cell. 2014 Aug 15;25(16):2472-84
pubmed: 24943837
BMC Bioinformatics. 2010 Mar 15;11:130
pubmed: 20230626
Mol Biol Evol. 2019 Feb 1;36(2):350-364
pubmed: 30445505
Heredity (Edinb). 1992 Oct;69(4):315-24
pubmed: 16718932
Heredity (Edinb). 2005 Apr;94(4):402-7
pubmed: 15523503
Bioinformatics. 2004 Oct 12;20(15):2471-2
pubmed: 15073005
Nat Methods. 2016 Dec;13(12):1050-1054
pubmed: 27749838
Bioinformatics. 2011 Mar 15;27(6):764-70
pubmed: 21217122
Proc Biol Sci. 2013 Jun 19;280(1764):20130823
pubmed: 23782880
J Cell Biol. 2003 Oct 13;163(1):165-76
pubmed: 14557253
Nat Protoc. 2013 Aug;8(8):1494-512
pubmed: 23845962
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Nat Methods. 2013 Jun;10(6):563-9
pubmed: 23644548
BMC Evol Biol. 2010 Jul 28;10:229
pubmed: 20667099
Genetics. 1998 Sep;150(1):275-82
pubmed: 9725846
Genes (Basel). 2018 Jun 12;9(6):
pubmed: 29895802
Cell. 2010 Feb 5;140(3):360-71
pubmed: 20144760
J Hered. 2002 Jan-Feb;93(1):77-8
pubmed: 12011185
Genetics. 1996 Aug;143(4):1727-38
pubmed: 8844159
J Evol Biol. 2011 Jan;24(1):12-22
pubmed: 20977519
BMC Genomics. 2011 Jan 19;12:48
pubmed: 21247459
J Evol Biol. 2017 May;30(5):868-888
pubmed: 28299861
Heredity (Edinb). 2014 Nov;113(5):424-31
pubmed: 24781809