A unique profile of serum cytokines in type 1 autoimmune pancreatitis and chronic rhinosinusitis.
Journal
Asian Pacific journal of allergy and immunology
ISSN: 0125-877X
Titre abrégé: Asian Pac J Allergy Immunol
Pays: Thailand
ID NLM: 8402034
Informations de publication
Date de publication:
21 Feb 2021
21 Feb 2021
Historique:
entrez:
27
2
2021
pubmed:
28
2
2021
medline:
28
2
2021
Statut:
aheadofprint
Résumé
Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD). Although AIP and IgG4-RD are characterized by multiple organ involvement including salivary glands, lung, and kidney, co-occurrence of chronic rhinosinusitis (CRS) and AIP/IgG4-RD has been poorly defined. We explored molecular mechanism accounting for the co-occurrence of CRS and AIP/IgG4-RD. Serum concentrations of IFN-α and IL-33 were measured by enzyme-linked immune-sorbent assay. We encountered a patient with concurrent type 1 AIP/IgG4-RD and CRS. Induction of remission by prednisolone (PSL) for type 1 AIP/IgG4-RD led to a marked improvement of CRS. Serum cytokine analysis after PSL treatment revealed a marked reduction in serum concentrations of IFN-α and IL-33, both of which are candidate pathogenic cytokines for AIP/IgG4-RD. Given that IL-33 is shared as one of pathogenic cytokines by type 1 AIP/IgG4-RD and CRS, enhanced IL33 responses may cause concurrent type 1 AIP/IgG4-RD and CRS.
Sections du résumé
BACKGROUND
BACKGROUND
Type 1 autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD). Although AIP and IgG4-RD are characterized by multiple organ involvement including salivary glands, lung, and kidney, co-occurrence of chronic rhinosinusitis (CRS) and AIP/IgG4-RD has been poorly defined.
OBJECTIVE
OBJECTIVE
We explored molecular mechanism accounting for the co-occurrence of CRS and AIP/IgG4-RD.
METHODS
METHODS
Serum concentrations of IFN-α and IL-33 were measured by enzyme-linked immune-sorbent assay.
RESULTS
RESULTS
We encountered a patient with concurrent type 1 AIP/IgG4-RD and CRS. Induction of remission by prednisolone (PSL) for type 1 AIP/IgG4-RD led to a marked improvement of CRS. Serum cytokine analysis after PSL treatment revealed a marked reduction in serum concentrations of IFN-α and IL-33, both of which are candidate pathogenic cytokines for AIP/IgG4-RD.
CONCLUSIONS
CONCLUSIONS
Given that IL-33 is shared as one of pathogenic cytokines by type 1 AIP/IgG4-RD and CRS, enhanced IL33 responses may cause concurrent type 1 AIP/IgG4-RD and CRS.
Identifiants
pubmed: 33638626
doi: 10.12932/AP-311020-0990
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM