Extended One-Generation Reproductive Toxicity (EOGRT) study of benzoic acid in Sprague Dawley rats.

Animals Benzoic Acid / pharmacology Body Weight Dose-Response Relationship, Drug Female Food Preservatives / pharmacology Genitalia / drug effects Male No-Observed-Adverse-Effect Level Organ Size / drug effects Rats Rats, Sprague-Dawley
Benzoic acid Extended one-generation reproductive toxicology study (EOGRTS) OECD 443

Journal

Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 11 12 2020
revised: 13 02 2021
accepted: 16 02 2021
pubmed: 28 2 2021
medline: 17 11 2021
entrez: 27 2 2021
Statut: ppublish

Résumé

Benzoic acid (BA) was administered in the diet to male and female Sprague Dawley Crl:CD(SD) rats in an OECD Test Guideline 443 Extended One-Generation Reproductive Toxicity (EOGRT) study to test for effects that may occur as a result of pre- and postnatal exposure. The study included cohorts of F

Identifiants

DOI: 10.1016/j.yrtph.2021.104897 PMID: 33639256
pubmed: 33639256
pii: S0273-2300(21)00037-4
doi: 10.1016/j.yrtph.2021.104897
pii:
doi:

Substances chimiques

Food Preservatives 0
Benzoic Acid 8SKN0B0MIM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104897

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Duncan Turnbull (D)

Ramboll US Consulting, Inc., 4350 North Fairfax Drive, Arlington, VA, 22203, USA. Electronic address: dturnbull@ramboll.com.

Maia M Jack (MM)

American Beverage Association, Science and Regulatory Affairs, 1275 Pennsylvania Ave. NW, Suite 1100, Washington, DC, 20004, USA.

Pragati S Coder (PS)

Charles River Laboratories Ashland Inc., 1407 George Road, Ashland, OH, 44805, USA.

Catherine A Picut (CA)

Charles River Laboratories Inc, 4025 Stirrup Creek Dr. Durham, NC, 27703, USA.

Joseph V Rodricks (JV)

Ramboll US Consulting, Inc., 4350 North Fairfax Drive, Arlington, VA, 22203, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Acide benzoïque › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Aliments et boissons › Aliments › Ingrédients alimentaires › Additifs alimentaires › Conservateurs alimentaires › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Appareil urogénital › Système génital › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Dose sans effet nocif observé › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Taille d'organe › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Extended One-Generation Reproductive Toxicity...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Extended One-Generation Reproductive Toxicity...