Clinical Efficacy of Cefixime for the Treatment of Early Syphilis.

Anti-Bacterial Agents / therapeutic use Cefixime / therapeutic use Humans Pilot Projects Syphilis / drug therapy Syphilis Serodiagnosis Treatment Outcome Treponema pallidum
Treponema pallidum cefixime early syphilis penicillin syphilis

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
07 09 2021
Historique:
received: 11 12 2020
pubmed: 1 3 2021
medline: 23 9 2021
entrez: 28 2 2021
Statut: ppublish

Résumé

Safe and efficacious alternative treatment options for syphilis are necessary. This randomized, 2-arm, noncomparative pilot study evaluated the efficacy of oral cefixime 400 mg in achieving a ≥4-fold rapid plasma reagin titer decrease by 3 or 6 months after treatment. The proportion of cefixime arm participants treated successfully was 87% (95% confidence interval, 69%-100%; 13/15). Clinical Trials Registration. NCT03752112.

Identifiants

DOI: 10.1093/cid/ciab187 PMID: 33640982 PMC: PMC8423500
pubmed: 33640982
pii: 6152217
doi: 10.1093/cid/ciab187
pmc: PMC8423500
doi:

Substances chimiques

Anti-Bacterial Agents 0
Cefixime 97I1C92E55

Banques de données

ClinicalTrials.gov
['NCT03752112']

Types de publication

Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

907-910

Subventions

Organisme : AIDS Healthcare Foundation
ID : 20181796

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

Auteurs

Chrysovalantis Stafylis (C)

Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
ORCID: 0000-0002-1486-1130

Kori Keith (K)

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

Shivani Mehta (S)

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

David Tellalian (D)

Department of Medicine, AIDS Healthcare Foundation, Los Angeles, California, USA.

Pamela Burian (P)

Department of Medicine, AIDS Healthcare Foundation, Los Angeles, California, USA.

Carl Millner (C)

Department of Medicine, AIDS Healthcare Foundation, Los Angeles, California, USA.

Jeffrey D Klausner (JD)

Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Clinical Efficacy of Cefixime for the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Céfacétrile › Céfotaxime › Céfixime › Clinical Efficacy of Cefixime for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Clinical Efficacy of Cefixime for the...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Clinical Efficacy of Cefixime for the...
questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Syphilis › Clinical Efficacy of Cefixime for the...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Tests sérologiques › Sérodiagnostic de la syphilis › Clinical Efficacy of Cefixime for the...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Clinical Efficacy of Cefixime for the...
questionsmedicales.fr › Bactéries › Spirochaetales › Spirochaetaceae › Treponema › Treponema pallidum › Clinical Efficacy of Cefixime for the...