α-Helical peptides on plasma-treated polymers promote ciliation of airway epithelial cells.
Airway
Biomaterial
Cilia
Peptide
Plasma treatment
Polymer
Journal
Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
09
11
2020
revised:
11
01
2021
accepted:
30
01
2021
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
Airway respiratory epithelium forms a physical barrier through intercellular tight junctions, which prevents debris from passing through to the internal environment while ciliated epithelial cells expel particulate-trapping mucus up the airway. Polymeric solutions to loss of airway structure and integrity have been unable to fully restore functional epithelium. We hypothesised that plasma treatment of polymers would permit adsorption of α-helical peptides and that this would promote functional differentiation of airway epithelial cells. Five candidate plasma compositions are compared; Air, N
Identifiants
pubmed: 33641925
pii: S0928-4931(21)00073-4
doi: 10.1016/j.msec.2021.111935
pii:
doi:
Substances chimiques
Peptides
0
Polymers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111935Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L01386X/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.