Association between nonalcoholic fatty liver disease and inflammatory periodontal disease: A case‑control study.
Bleeding on probing
case control
nonalcoholic fatty liver disease
oral health
periodontal disease
systemic health
tumor necrosis factor
Journal
Journal of Indian Society of Periodontology
ISSN: 0972-124X
Titre abrégé: J Indian Soc Periodontol
Pays: India
ID NLM: 101499342
Informations de publication
Date de publication:
Historique:
received:
26
01
2020
revised:
17
04
2020
accepted:
28
04
2020
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
2
3
2021
Statut:
ppublish
Résumé
Recent evidence suggests an interconnection between chronic periodontal disease and systemic diseases. The aim of this study is to evaluate the possible association between nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease among north Indian population. Tertiary health care center, cross-sectional case-control observational study. A total of 40 cases, i.e., patients with NAFLD and 40 healthy volunteers were included over a period of 8 months and their periodontal status was compared. The status of their hepatic health was ascertained by anthropometric, imaging, and biochemical evaluation including ultrasound examination of abdomen and transient elastography. Paired The study revealed that only 11.9% and 20% of participants had periodontitis, in healthy controls and hepatic disease patients, respectively. A statistically significant difference was observed in clinical parameters of periodontal status, except for malocclusion. Comparative analysis of tumor necrosis factor-α (TNF-α), interleukin-6, C-reactive protein, and cytokeratin-18 revealed differences in mean scores, though statistically nonsignificant. Only aspartate transaminase, number of missing teeth, and bleeding on probing (BOP) were observed with higher odds ratios for hepatic disease patients. Spearman correlation analysis revealed significant positive correlations between TNF-α and BOP, for cases. Patients with hepatic disease showed a higher prevalence of periodontal disease, worse oral hygiene and periodontal health status compared to healthy individuals.
Sections du résumé
BACKGROUND
BACKGROUND
Recent evidence suggests an interconnection between chronic periodontal disease and systemic diseases.
AIM
OBJECTIVE
The aim of this study is to evaluate the possible association between nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease among north Indian population.
SETTINGS AND DESIGN
METHODS
Tertiary health care center, cross-sectional case-control observational study.
MATERIALS AND METHODS
METHODS
A total of 40 cases, i.e., patients with NAFLD and 40 healthy volunteers were included over a period of 8 months and their periodontal status was compared. The status of their hepatic health was ascertained by anthropometric, imaging, and biochemical evaluation including ultrasound examination of abdomen and transient elastography.
STATISTICAL DATA ANALYSIS
UNASSIGNED
Paired
RESULTS
RESULTS
The study revealed that only 11.9% and 20% of participants had periodontitis, in healthy controls and hepatic disease patients, respectively. A statistically significant difference was observed in clinical parameters of periodontal status, except for malocclusion. Comparative analysis of tumor necrosis factor-α (TNF-α), interleukin-6, C-reactive protein, and cytokeratin-18 revealed differences in mean scores, though statistically nonsignificant. Only aspartate transaminase, number of missing teeth, and bleeding on probing (BOP) were observed with higher odds ratios for hepatic disease patients. Spearman correlation analysis revealed significant positive correlations between TNF-α and BOP, for cases.
CONCLUSION
CONCLUSIONS
Patients with hepatic disease showed a higher prevalence of periodontal disease, worse oral hygiene and periodontal health status compared to healthy individuals.
Identifiants
pubmed: 33642741
doi: 10.4103/jisp.jisp_45_20
pii: JISP-25-47
pmc: PMC7904021
doi:
Types de publication
Journal Article
Langues
eng
Pagination
47-54Informations de copyright
Copyright: © 2020 Journal of Indian Society of Periodontology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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