Complementary roles of mechanotransduction and inflammation in vascular homeostasis.
artery
homeostasis
hypertension
inflammation
mechanotransduction
Journal
Proceedings. Mathematical, physical, and engineering sciences
ISSN: 1364-5021
Titre abrégé: Proc Math Phys Eng Sci
Pays: England
ID NLM: 9891746
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
31
07
2020
accepted:
09
12
2020
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
2
3
2021
Statut:
ppublish
Résumé
Arteries are exposed to relentless pulsatile haemodynamic loads, but via mechanical homeostasis they tend to maintain near optimal structure, properties and function over long periods in maturity in health. Numerous insults can compromise such homeostatic tendencies, however, resulting in maladaptations or disease. Chronic inflammation can be counted among the detrimental insults experienced by arteries, yet inflammation can also play important homeostatic roles. In this paper, we present a new theoretical model of complementary mechanobiological and immunobiological control of vascular geometry and composition, and thus properties and function. We motivate and illustrate the model using data for aortic remodelling in a common mouse model of induced hypertension. Predictions match the available data well, noting a need for increased data for further parameter refinement. The overall approach and conclusions are general, however, and help to unify two previously disparate literatures, thus leading to deeper insight into the separate and overlapping roles of mechanobiology and immunobiology in vascular health and disease.
Identifiants
pubmed: 33642928
doi: 10.1098/rspa.2020.0622
pii: rspa20200622
pmc: PMC7897647
doi:
Banques de données
figshare
['10.6084/m9.figshare.c.5253529']
Types de publication
Journal Article
Langues
eng
Pagination
20200622Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL134605
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146723
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
We declare we have no competing interests.
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