The Role of Long-Term Head-Down Bed Rest in Understanding Inter-Individual Variation in Response to the Spaceflight Environment: A Perspective Review.

bed rest cardiorespiratory countermeasure exercise inter-individual variability microgravity musculoskeletal spaceflight

Journal

Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006

Informations de publication

Date de publication:
2021
Historique:
received: 06 10 2020
accepted: 04 01 2021
entrez: 1 3 2021
pubmed: 2 3 2021
medline: 2 3 2021
Statut: epublish

Résumé

Exposure to the spaceflight environment results in profound multi-system physiological adaptations in which there appears to be substantial inter-individual variability (IV) between crewmembers. However, performance of countermeasure exercise renders it impossible to separate the effects of the spaceflight environment

Identifiants

pubmed: 33643065
doi: 10.3389/fphys.2021.614619
pmc: PMC7904881
doi:

Types de publication

Journal Article

Langues

eng

Pagination

614619

Informations de copyright

Copyright © 2021 Scott, Kramer, Petersen and Green.

Déclaration de conflit d'intérêts

JS, NP, and DG are all employed by KBR GmbH, Cologne, Germany. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Aviat Space Environ Med. 1992 Nov;63(11):1004-10
pubmed: 1445150
Front Physiol. 2019 Mar 07;10:173
pubmed: 30899226
Adv Clin Chem. 2008;46:87-130
pubmed: 19004188
Eur J Appl Physiol. 2007 Sep;101(2):143-94
pubmed: 17661073
NPJ Microgravity. 2016 Aug 18;2:16029
pubmed: 28725737
Acta Astronaut. 2020 Oct;175:290-299
pubmed: 32801403
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A1-A6
pubmed: 26630187
Life Sci Space Res (Amst). 2019 Feb;20:113-123
pubmed: 30797428
Aerosp Med Hum Perform. 2018 Sep 1;89(9):805-815
pubmed: 30126513
Aviat Space Environ Med. 2011 Jun;82(6):615-21
pubmed: 21702312
Med Sci Sports Exerc. 2001 Jun;33(6 Suppl):S446-51; discussion S452-3
pubmed: 11427769
PLoS One. 2012;7(5):e37887
pubmed: 22666405
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A14-A23
pubmed: 26630191
J Bone Miner Res. 2004 Aug;19(8):1231-40
pubmed: 15231009
Sci Rep. 2020 Aug 14;10(1):13836
pubmed: 32796944
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A54-A67
pubmed: 26630196
Front Physiol. 2019 Mar 29;10:321
pubmed: 30984019
Am J Clin Nutr. 2018 May 1;107(5):834-844
pubmed: 29722847
Sci Rep. 2017 Oct 13;7(1):13177
pubmed: 29030644
J Appl Physiol (1985). 2016 Apr 15;120(8):891-903
pubmed: 26893033
J Physiol. 2005 Jun 15;565(Pt 3):993-1005
pubmed: 15845588
J Appl Physiol (1985). 2016 Jul 1;121(1):348-9
pubmed: 26917693
Exp Physiol. 2015 Jun;100(6):577-88
pubmed: 25823596
J Bone Miner Res. 1995 Oct;10(10):1544-9
pubmed: 8686511
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A7-A13
pubmed: 26630190
Nutrition. 2002 Oct;18(10):829-36
pubmed: 12361774
Sports Med. 2015 Oct;45(10):1469-81
pubmed: 26243014
NPJ Microgravity. 2018 Sep 17;4:18
pubmed: 30246141
Sports Med. 2019 Jan;49(1):1-7
pubmed: 30560423
Exerc Sport Sci Rev. 1994;22:91-120
pubmed: 7925554
Pflugers Arch. 2000;441(2-3 Suppl):R21-31
pubmed: 11200976
Sci Rep. 2015 Dec 16;5:17627
pubmed: 26671177
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A38-A44
pubmed: 26630194
Med Sci Sports Exerc. 2018 Sep;50(9):1961-1980
pubmed: 29620686
J Bone Miner Res. 2013 Jun;28(6):1243-55
pubmed: 23553962
Med Sci Sports Exerc. 1997 Feb;29(2):191-6
pubmed: 9044222
J Physiol. 2020 Oct;598(19):4237-4249
pubmed: 32715482
Eur J Appl Physiol. 2020 May;120(5):1155-1164
pubmed: 32236752
Aviat Space Environ Med. 2009 May;80(5 Suppl):A23-8
pubmed: 19476166
Sports Med. 2018 Sep;48(9):2169-2178
pubmed: 29949108
Am J Physiol Regul Integr Comp Physiol. 2007 Feb;292(2):R988-96
pubmed: 17068163
Calcif Tissue Int. 1992 Apr;50(4):306-13
pubmed: 1571841
PLoS One. 2017 Jan 12;12(1):e0169793
pubmed: 28081223
Front Physiol. 2017 Aug 02;8:547
pubmed: 28824446
Life (Basel). 2014 Sep 11;4(3):491-510
pubmed: 25370382
Front Physiol. 2019 Sep 13;10:1115
pubmed: 31572205
Aerosp Med Hum Perform. 2015 Dec;86(12 Suppl):A68-A77
pubmed: 26630197
J Appl Physiol Respir Environ Exerc Physiol. 1984 Nov;57(5):1369-74
pubmed: 6520029
Sports Med. 2019 Dec;49(Suppl 2):139-151
pubmed: 31696454
Aviat Space Environ Med. 1985 Oct;56(10):985-90
pubmed: 4062772
J Appl Physiol (1985). 2011 Mar;110(3):846-53
pubmed: 21030666
Acta Physiol (Oxf). 2010 Aug;199(4):549-56
pubmed: 20345416
Int J Exerc Sci. 2018 May 01;11(4):198-213
pubmed: 29795731
Nutrition. 2002 Oct;18(10):867-71
pubmed: 12361781
Phys Med. 2001;17 Suppl 1:5-12
pubmed: 11770537
Sports Med. 2017 Aug;47(8):1501-1513
pubmed: 28097487
J Appl Physiol (1985). 2014 Aug 1;117(3):231-8
pubmed: 24970852
BMC Musculoskelet Disord. 2018 Jul 18;19(1):223
pubmed: 30021585

Auteurs

Jonathan P R Scott (JPR)

Space Medicine Team, ISS Operations and Astronaut Group, Directorate of Human and Robotic Exploration, European Space Agency, Cologne, Germany.
KBR GmbH, Cologne, Germany.

Andreas Kramer (A)

Department of Sport Science, University of Konstanz, Konstanz, Germany.

Nora Petersen (N)

Space Medicine Team, ISS Operations and Astronaut Group, Directorate of Human and Robotic Exploration, European Space Agency, Cologne, Germany.
KBR GmbH, Cologne, Germany.

David A Green (DA)

Space Medicine Team, ISS Operations and Astronaut Group, Directorate of Human and Robotic Exploration, European Space Agency, Cologne, Germany.
KBR GmbH, Cologne, Germany.
Centre of Human and Applied Physiology, King's College London, London, United Kingdom.

Classifications MeSH