The Role of Alpha 2 Macroglobulin in IgG-Aggregation and Chronic Activation of the Complement System in Patients With Chronic Lymphocytic Leukemia.
Aged
Aged, 80 and over
Antigens
B-Lymphocytes
/ immunology
Case-Control Studies
Cell Membrane
/ immunology
Complement Activation
Endoplasmic Reticulum Chaperone BiP
Female
Heat-Shock Proteins
/ metabolism
Humans
Immunoglobulin G
/ blood
Leukemia, Lymphocytic, Chronic, B-Cell
/ blood
Male
Middle Aged
Protein Aggregates
alpha-Macroglobulins
/ metabolism
IgG-hexamers,
alpha 2 macroglobulin
chronic lymphocytic leukemia
classical pathway
complement system
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
09
2020
accepted:
31
12
2020
entrez:
1
3
2021
pubmed:
2
3
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in the western world. One of the treatments offered for CLL is immunotherapy. These treatments activate various cellular and biochemical mechanisms, using the complement system. Recently it was shown that the complement system in CLL patients is persistently activated at a low level through the classical pathway (CP). The mechanism of chronic CP activation involves the formation of IgG-hexamers (IgG-aggregates). According to recent studies, formation of ordered IgG-hexamers occurs on cell surfaces
Identifiants
pubmed: 33643290
doi: 10.3389/fimmu.2020.603569
pmc: PMC7905172
doi:
Substances chimiques
A2M protein, human
0
Antigens
0
Endoplasmic Reticulum Chaperone BiP
0
Heat-Shock Proteins
0
Immunoglobulin G
0
Protein Aggregates
0
alpha-Macroglobulins
0
Banques de données
Dryad
['10.5061/dryad.tmpg4f4xg']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
603569Informations de copyright
Copyright © 2021 Naseraldeen, Michelis, Barhoum, Chezar, Tadmor, Aviv, Shvidel, Litmanovich, Shehadeh, Stemer, Shaoul and Braester.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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