Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration.

diabetes ischemia myocardial infarction nidogen‐1 pancreatic β‐cells

Journal

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569

Informations de publication

Date de publication:
Feb 2021
Historique:
received: 02 07 2020
revised: 25 10 2020
entrez: 1 3 2021
pubmed: 2 3 2021
medline: 2 3 2021
Statut: epublish

Résumé

Ischemia impacts multiple organ systems and is the major cause of morbidity and mortality in the developed world. Ischemia disrupts tissue homeostasis, driving cell death, and damages tissue structure integrity. Strategies to heal organs, like the infarcted heart, or to replace cells, as done in pancreatic islet

Identifiants

pubmed: 33643791
doi: 10.1002/advs.202002500
pii: ADVS2248
pmc: PMC7887579
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2002500

Informations de copyright

© 2020 The Authors. Advanced Science published by Wiley‐VCH GmbH.

Déclaration de conflit d'intérêts

A.Z., S.L.L., G.P.D., and K.S.‐L. are inventors on patent application EP19154849.4 associated with this work and owned by the University Tübingen. S.L.L., M.Z., and K.S.‐L. are inventors on patents (EP3027201B1 and CN105517564A), and patent applications (US20160158314A1, CA2916614A1, JP2016530532A, and KR20160037170A) associated with this work and owned by the NMI, Reutlingen.

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Auteurs

Aline Zbinden (A)

Department of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.

Shannon L Layland (SL)

Department of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.

Max Urbanczyk (M)

Department of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.

Daniel A Carvajal Berrio (DA)

Department of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies" Eberhard Karls University Tübingen Tübingen 72076 Germany.

Julia Marzi (J)

Department of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies" Eberhard Karls University Tübingen Tübingen 72076 Germany.
NMI Natural and Medical Sciences Institute at the University of Tübingen Reutlingen 72770 Germany.

Monika Zauner (M)

Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.

Anne Hammerschmidt (A)

Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.

Eva M Brauchle (EM)

Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies" Eberhard Karls University Tübingen Tübingen 72076 Germany.
NMI Natural and Medical Sciences Institute at the University of Tübingen Reutlingen 72770 Germany.

Katrin Sudrow (K)

Institute of Medical Immunology Charité Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin Berlin 10117 Germany.
Charité Universitätsmedizin Berlin Institute of Health (BIH) Center for Regenerative Therapies Berlin (BCRT) Berlin 10178 Germany.

Simon Fink (S)

NMI Natural and Medical Sciences Institute at the University of Tübingen Reutlingen 72770 Germany.

Markus Templin (M)

NMI Natural and Medical Sciences Institute at the University of Tübingen Reutlingen 72770 Germany.

Simone Liebscher (S)

Department of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.

Gerd Klein (G)

Center for Medical Research Department of Medicine II Eberhard Karls University Tübingen Tübingen 72076 Germany.

Arjun Deb (A)

Department of Molecular Cell and Developmental Biology UCLA Los Angeles CA 90095 USA.
Eli and Edythe Broad Stem Cell Research Center UCLA Los Angeles CA 90095 USA.
Molecular Biology Institute UCLA Los Angeles CA 90095 USA.
Jonsson Comprehensive Cancer Center UCLA Los Angeles CA 90024 USA.
Department of Medicine/Cardiology Cardiovascular Research Laboratories David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA.

Garry P Duffy (GP)

Anatomy and Regenerative Medicine Institute School of Medicine College of Medicine Nursing and Health Sciences National University of Ireland Galway Galway H91TK33 Ireland.

Gay M Crooks (GM)

Eli and Edythe Broad Stem Cell Research Center UCLA Los Angeles CA 90095 USA.
Jonsson Comprehensive Cancer Center UCLA Los Angeles CA 90024 USA.
Department of Pathology and Laboratory Medicine, and Pediatrics David Geffen School of Medicine at UCLA UCLA Los Angeles CA 90095 USA.

Johannes A Eble (JA)

Institute of Physiological Chemistry and Pathobiochemistry University of Münster Münster 48149 Germany.

Hanna K A Mikkola (HKA)

Department of Molecular Cell and Developmental Biology UCLA Los Angeles CA 90095 USA.
Eli and Edythe Broad Stem Cell Research Center UCLA Los Angeles CA 90095 USA.
Molecular Biology Institute UCLA Los Angeles CA 90095 USA.
Jonsson Comprehensive Cancer Center UCLA Los Angeles CA 90024 USA.

Ali Nsair (A)

Eli and Edythe Broad Stem Cell Research Center UCLA Los Angeles CA 90095 USA.
Department of Medicine/Cardiology Cardiovascular Research Laboratories David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA.

Martina Seifert (M)

Institute of Medical Immunology Charité Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu Berlin Berlin 10117 Germany.
Charité Universitätsmedizin Berlin Institute of Health (BIH) Center for Regenerative Therapies Berlin (BCRT) Berlin 10178 Germany.
DZHK (German Centre for Cardiovascular Research) partner site Berlin Berlin 10117 Germany.

Katja Schenke-Layland (K)

Department of Bioengineering Eberhard Karls University Tübingen Tübingen 72076 Germany.
Department of Women's Health Research Institute for Women's Health Eberhard Karls University Tübingen Tübingen 72076 Germany.
Cluster of Excellence iFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies" Eberhard Karls University Tübingen Tübingen 72076 Germany.
NMI Natural and Medical Sciences Institute at the University of Tübingen Reutlingen 72770 Germany.
Department of Medicine/Cardiology Cardiovascular Research Laboratories David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA.

Classifications MeSH